{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:26:33Z","timestamp":1768476393047,"version":"3.49.0"},"reference-count":45,"publisher":"Oceanside Publications Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> There is a lack of studies about which factors affect the quality of life (QoL) in children with atopic dermatitis (AD), although it is well known that AD has considerably negative effects on their QoL.  <jats:bold>Objective:<\/jats:bold> This study aimed to measure\n the QoL in children with AD and identify the factors that affect their QoL.  <jats:bold>Methods:<\/jats:bold> A questionnaire derived from the Children\u2019s Dermatology Life Quality Index (CDLQI) was used to measure QoL. Family history, allergic comorbidities, exacerbation-related factors, time\n of exacerbation, and previous and current treatment were also evaluated. The total immunoglobulin E (IgE) level and specific IgE sensitization were determined by the multiple allergen simultaneous test, allergy test, or skin-prick test. AD severity was categorized into mild, moderate, and\n severe based on treatments.  <jats:bold>Results:<\/jats:bold> In total, 254 children (46.4 months, 53% boys) from seven hospitals completed the survey. The mean CDLQI score was 7.2 <jats:italic>\u00b1<\/jats:italic> 5.5 (total score range of 0\u201030). The respondents were divided into three groups according to\n their QoL score distribution, with 0 \u2212 4 points (n = 84), 5 \u2212 9 points (n = 90), and \u226510 points (n = 80) representing good, fair, and poor QoL, respectively. The more severe AD showed the higher CDLQI score significantly (p\u2009=\u20090.001). Compared with other groups,\n children with poor QoL were more sensitized to inhalant allergens (odds ratio [OR] 1.29 [95% confidence interval {CI}], 1.03 \u2212 1.62) and had more exacerbating factors (OR 1.26 [95% CI, 1.04 \u2212 1.54]), which included inhalation allergen\u2010related exacerbating factors (OR 2.54\n [95% CI, 1.23 \u2212 5.23), even after adjusting for age, total IgE, body mass index, severity, and use of moisturizer. The concordance between animal sensitization and an exacerbating factor, including dog and cat, was fair, with 0.39 \u03ba and 0.85 accuracy.  <jats:bold>Conclusion:<\/jats:bold>\n This study showed that impaired QoL in children with AD is associated with inhalant allergen sensitization and inhalant allergen\u2010related exacerbation factors. Especially, dog and cat sensitization was a significant exacerbating factor. The inhalation-related exacerbation factors,\n including animal allergens, might be addressed to improve AD management in children.<\/jats:p>","DOI":"10.2500\/aap.2024.45.230094","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T04:30:48Z","timestamp":1709785848000},"page":"112-119","source":"Crossref","is-referenced-by-count":2,"title":["Factors influencing the quality of life in children with atopic dermatitis in Korea: A multicenter cross-sectional study"],"prefix":"10.2500","volume":"45","author":[{"given":"Mireu","family":"Park","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Yung","family":"Yum","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul Medical Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung 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