{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:24:14Z","timestamp":1774542254364,"version":"3.50.1"},"reference-count":48,"publisher":"Oceanside Publications Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Asthma is the most prevalent chronic respiratory disease in children, and gastroesophageal reflux disease (GERD) is one of its extraesophageal complications of asthma. Both conditions are commonly observed in pediatric outpatient clinics, but the causality between\n them in children is still debated. Therefore, we conducted a systematic review and meta-analysis to evaluate the bidirectional association between asthma and GERD in children.  <jats:bold>Methods:<\/jats:bold> We systematically reviewed original studies published from January 2000 to February 2024\n by searching the data bases. We also performed manual retrieval and screening to identify studies that met the inclusion criteria. The quality of the final included studies was evaluated by using the Newcastle\u2010Ottawa Scale, and outcome measures were extracted.  <jats:bold>Results:<\/jats:bold>\n We identified nine eligible studies, which included 304,399 children of different ages from seven countries. Overall, the risk of developing GERD in children with asthma (odds ratio [OR] 2.16 [95% confidence interval [CI], 1.6\u20102.91) was higher than the risk of developing asthma\n in children with GERD (OR 1.55 [95% CI, 1.32\u20101.82]).  <jats:bold>Conclusion:<\/jats:bold> Based on the available studies, it can be concluded that asthma and GERD are mutually aggravating factors in children, presenting a bidirectional association. However, the risk of developing GERD in\n children with asthma is higher to some extent. More large-scale and high-quality prospective cohort studies are needed in the future to provide richer evidence and more research opportunities.<\/jats:p>","DOI":"10.2500\/aap.2024.45.240085","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T04:32:18Z","timestamp":1731126738000},"page":"e101-e110","source":"Crossref","is-referenced-by-count":3,"title":["A systematic review and meta-analysis exploring the bidirectional association between asthma and gastroesophageal reflux disease in children"],"prefix":"10.2500","volume":"45","author":[{"given":"KaiWen","family":"Zheng","sequence":"first","affiliation":[{"name":"From the School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"From the School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LinYan","family":"Tang","sequence":"additional","affiliation":[{"name":"From the School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Respiratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Clinical Research Center for Children\u2019s Health and Disease Office, Ji\u2019nan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YuLing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Respiratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Clinical Research Center for Children\u2019s Health and Disease Office, Ji\u2019nan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Respiratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Clinical Research Center for Children\u2019s Health and Disease Office, Ji\u2019nan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2222.1999.00009.x","article-title":"Role of respiratory infection in onset of asthma and chronic obstructive pulmonary disease","volume":"29","author":"Martinez","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"B2","doi-asserted-by":"crossref","first-page":"4S","DOI":"10.1378\/chest.130.1_suppl.4S","article-title":"The global burden of asthma","volume":"130","author":"Braman","year":"2006","journal-title":"Chest"},{"key":"B3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3389\/fped.2018.00186","article-title":"The burden of pediatric asthma","volume":"6","author":"Ferrante","year":"2018","journal-title":"Front Pediatr"},{"key":"B4","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1513\/AnnalsATS.201404-138OC","article-title":"Asthma deaths in a large provincial health system. 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asthma","volume":"115","author":"Canning","year":"2003","journal-title":"Am J Med"},{"key":"B12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41533-018-0103-9","article-title":"Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations","volume":"28","author":"Yang","year":"2018","journal-title":"NPJ Prim Care Respir Med"},{"key":"B13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3109\/02770903.2013.879881","article-title":"Coexisting chronic conditions associated with mortality and morbidity in adult patients with asthma","volume":"51","author":"Sumino","year":"2014","journal-title":"J Asthma"},{"key":"B14","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41390-020-0749-1","article-title":"Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national sample 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