{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T16:05:07Z","timestamp":1773763507281,"version":"3.50.1"},"reference-count":26,"publisher":"Oceanside Publications Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Selective immunoglobulin E deficiency (sIgED) is a rare condition characterized by low serum IgE levels with normal levels of other immunoglobulin classes. The prevalence of sIgED varies considerably across populations, with a higher prevalence observed in clinical\n settings. Studies report sIgED prevalence that ranges up to 9.7% in patients attending rheumatology clinics, 8.1% in allergy\/immunology clinics, and 2.6% in healthy blood donors. Its role in immune regulation and association with autoimmune and autoinflammatory disorders remains poorly understood.\n  <jats:bold>Objective:<\/jats:bold> This study aimed to investigate the relationship between sIgED and immune-mediated diseases by hypothesizing that sIgED may predispose individuals to an increased prevalence of these conditions.  <jats:bold>Methods:<\/jats:bold> This retrospective cohort study analyzed\n data from 3692 patients at a tertiary care center between November 2018 and December 2023. Patients with IgE levels \u22642.5 IU\/mL and normal levels of other immunoglobulin classes were classified as having sIgED, whereas those with IgE levels &gt;2.5 IU\/mL served as controls. Autoimmune and\n autoinflammatory diseases were identified by using medical records and International Classification of Diseases codes. Statistical analyses were performed to compare the prevalence of these conditions between the groups.  <jats:bold>Results:<\/jats:bold> The prevalence of autoimmune and autoinflammatory\n diseases was significantly higher in the sIgED group versus controls (25.2% versus 15.6%; p\u2009&lt;\u20090.001). Conditions such as Hashimoto thyroiditis, vitiligo, familial Mediterranean fever, and Beh\u00e7et disease were disproportionately observed in patients with sIgED. Demographic\n characteristics, including age and gender, were not significantly different between the groups (p\u2009=\u20090.171 and p\u2009=\u20090.257, respectively).  <jats:bold>Conclusion:<\/jats:bold> The sIgED is associated with a higher prevalence of autoimmune and autoinflammatory diseases,\n which underscores its potential role in immune dysregulation. This finding highlights the need for further prospective, multicenter studies to validate these associations, elucidate underlying mechanisms, and explore potential clinical implications of IgE deficiency in immune-mediated pathologies.<\/jats:p>","DOI":"10.2500\/aap.2025.46.250016","type":"journal-article","created":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T00:32:27Z","timestamp":1747441947000},"page":"e91-e97","source":"Crossref","is-referenced-by-count":4,"title":["Selective immunoglobulin E deficiency and its association with autoimmune and autoinflammatory diseases"],"prefix":"10.2500","volume":"46","author":[{"given":"Mehmet Emin","family":"Gerek","sequence":"first","affiliation":[{"name":"From the Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Colkesen","sequence":"additional","affiliation":[{"name":"From the Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tugba","family":"Onalan","sequence":"additional","affiliation":[{"name":"From the Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Arzu","family":"Akkus","sequence":"additional","affiliation":[{"name":"From the Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Kilinc","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Allergy, Batman Training and Research Hospital, Batman, Turkey; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Recep","family":"Evcen","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Allergy, Rize Training and Research Hospital, Rize, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selim","family":"Kahraman","sequence":"additional","affiliation":[{"name":"From the Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevket","family":"Arslan","sequence":"additional","affiliation":[{"name":"From the Division of Clinical Immunology and Allergy, Department of Internal 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