{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:14:30Z","timestamp":1754144070217,"version":"3.41.2"},"reference-count":30,"publisher":"Oceanside Publications Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"Background:<\/jats:bold> It is unclear whether the continuous use of a high dose of inhaled corticosteroids (ICS) could contribute to an unfavorable trajectory in body weight. Objectives:<\/jats:bold> The objective was to evaluate whether a high dose of ICS used continuously for\n maintenance therapy increases the risk of an unfavorable body weight trajectory in individuals with asthma and who are not obese. Methods:<\/jats:bold> We screened consecutive individuals with chronic respiratory symptoms suggestive of asthma who underwent a medical consultation in\n any of the 42 public health facilities in the municipality of Jundia\u00ed, Brazil. We included individuals with proven asthma who were \u2265 20 years of age and who had a body mass index (BMI)\u2009<\u200930 kg\/m2<\/jats:sup> on the day of screening for the study. Individuals participated\n in two study visits 12 months apart, named V1<\/jats:sub> and V2<\/jats:sub>. Between study visits, individuals had one intermediate consultation with their referring physician. Results:<\/jats:bold> Ninety-nine individuals used a high dose of ICS during the study and 294 used a low-medium\n dose. The individual with asthma and no obesity and who used a high dose of ICS had a similar risk of having obesity at V2<\/jats:sub> compared with those who used a low-medium dose (adjusted odds ratio 1.18 [95% confidence interval, 0.46\u20103.04]). The probability of gaining weight was\n similar between the two groups. Conclusion:<\/jats:bold> The use of a high dose of ICS for 1 year does not increase the risk of obesity among individuals with asthma and who are not obese, nor is it associated with an unfavorable body weight trajectory compared with individuals with\n asthma who were using a low-medium dose of ICS. This information may help reduce fears about using ICS.<\/jats:p>","DOI":"10.2500\/aap.2025.46.250041","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:34:02Z","timestamp":1751934842000},"page":"296-303","source":"Crossref","is-referenced-by-count":1,"title":["Body weight trajectory of non-obese asthmatics: Relationship with inhaled corticosteroids maintenance therapy"],"prefix":"10.2500","volume":"46","author":[{"given":"Monique Olivia","family":"Burch","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine, Jundia\u00ed School of Medicine, Jundia\u00ed, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Gimenez","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Unianchieta, Jundia\u00ed, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Belleze","sequence":"additional","affiliation":[{"name":"Department of Speech Therapy, Unianchieta, Jundia\u00ed, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Jose Oliveira","family":"Da Silva","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Jundia\u00ed School of Medicine, Jundia\u00ed, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Pletsch","family":"Assuncao","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Unianchieta, Jundia\u00ed, Brazil; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Antunes","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Jundia\u00ed School of Medicine, Jundia\u00ed, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronei Luciano","family":"Mamoni","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jundia\u00ed School of Medicine, Jundia\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Vieira","family":"Ponte","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Jundia\u00ed School of Medicine, Jundia\u00ed, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/s41366-021-00788-4","article-title":"Weight loss and risk reduction of obesity-related outcomes in 0.5 million people: evidence from a UK primary care database","volume":"45","author":"Haase","year":"2021","journal-title":"Int J Obes (Lond)"},{"key":"B2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/thoraxjnl-2021-217867","article-title":"Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS","volume":"78","author":"Moitra","year":"2023","journal-title":"Thorax"},{"key":"B3","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jaip.2015.03.017","article-title":"Prospective study on the relationship of obesity to asthma impairment and risk","volume":"3","author":"Schatz","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B4","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.anai.2022.01.004","article-title":"Persistent overweight or obesity, lung function, and asthma exacerbations in Puerto Rican youth","volume":"128","author":"Wong","year":"2022","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B5","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jaip.2021.10.020","article-title":"Obesity is associated with sustained symptomatology and unique inflammatory features in children with asthma","volume":"10","author":"Fitzpatrick","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B6","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/thorax-2022-219268","article-title":"Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis","volume":"78","author":"Scott","year":"2023","journal-title":"Thorax"},{"key":"B7","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1513\/AnnalsATS.201810-651SR","article-title":"Weight loss for children and adults with obesity and asthma. A systematic review of randomized controlled trials","volume":"16","author":"Okoniewski","year":"2019","journal-title":"Ann Am Thorac Soc"},{"key":"B8","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.jaip.2022.02.040","article-title":"An online weight loss intervention for people with obesity and poorly controlled asthma","volume":"10","author":"Johnson","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B9","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.chest.2023.01.015","article-title":"A total diet replacement weight management program for difficult-to-treat asthma associated with obesity: a randomized controlled feasibility trial","volume":"163","author":"Sharma","year":"2023","journal-title":"Chest"},{"key":"B10","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jaci.2014.12.1931","article-title":"Risk of an asthma exacerbation after bariatric surgery in adults","volume":"136","author":"Hasegawa","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"B11","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1378\/chest.14-3105","article-title":"Effects of weight loss on airway responsiveness in obese adults with asthma: does weight loss lead to reversibility of asthma?","volume":"147","author":"Pakhale","year":"2015","journal-title":"Chest"},{"key":"B12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1152\/japplphysiol.00341.2018","article-title":"Effects of weight loss on dynamic hyperinflation in obese women asthmatics","volume":"126","author":"Grandi Silva","year":"2019","journal-title":"J Appl Physiol (1985)"},{"key":"B13","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.rmed.2011.12.012","article-title":"Effect of bariatric surgery on airway response and lung function in obese subjects with asthma","volume":"106","author":"Boulet","year":"2012","journal-title":"Respir Med"},{"key":"B14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/thoraxjnl-2014-206712","article-title":"Effect of bariatric surgery on asthma control, lung function and bronchial and systemic inflammation in morbidly obese subjects with asthma","volume":"70","author":"van Huisstede","year":"2015","journal-title":"Thorax"},{"key":"B15","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1159\/000345840","article-title":"Reduction in the leptin concentration as a predictor of improvement in lung function in obese adolescents","volume":"5","author":"Le\u00e3o da Silva","year":"2012","journal-title":"Obes Facts"},{"key":"B16","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/oby.20524","article-title":"Increase in the mediators of asthma in obesity and obesity with type 2 diabetes: reduction with weight loss","volume":"22","author":"Dandona","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"B17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.rmed.2018.10.017","article-title":"Influence of weight loss on pulmonary function and levels of adipokines among asthmatic individuals with obesity: one-year follow-up","volume":"145","author":"Baltieri","year":"2018","journal-title":"Respir Med"},{"key":"B18","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.3390\/jcm11133782","article-title":"Differences in inflammatory cytokine profile in obesity-associated asthma: effects of weight loss","volume":"11","author":"Bantul\u00e0","year":"2022","journal-title":"J Clin Med"},{"key":"B19","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1016\/j.jaip.2023.06.054","article-title":"Long-term weight changes after starting anti-IL-5\/5Ra biologics in severe asthma: the role of oral corticosteroids","volume":"11","author":"Ten Have","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1590\/s1806-37562017000000034","article-title":"Obesity and asthma: clinical and laboratory characterization of a common combination","volume":"44","author":"Jesus","year":"2018","journal-title":"J Bras Pneumol"},{"key":"B21","doi-asserted-by":"crossref","first-page":"00497","DOI":"10.1183\/23120541.00497-2020","article-title":"What matters to people with severe asthma? Exploring add-on asthma medication and outcomes of importance","volume":"7","author":"Clark","year":"2021","journal-title":"ERJ Open Res"},{"key":"B22","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1210\/jc.2015-1218","article-title":"Adrenal insufficiency in corticosteroids use: systematic review and meta-analysis","volume":"100","author":"Broersen","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B23","doi-asserted-by":"crossref","first-page":"e0133428","DOI":"10.1371\/journal.pone.0133428","article-title":"Impact of inhaled corticosteroids on growth in children with asthma: systematic review and meta-analysis","volume":"10","author":"Loke","year":"2015","journal-title":"PLoS One"},{"key":"B24","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1183\/09031936.06.00043005","article-title":"Low-dose inhaled and nasal corticosteroid use and the risk of cataracts","volume":"27","author":"Ernst","year":"2006","journal-title":"Eur Respir J"},{"key":"B25","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.amjmed.2010.06.019","article-title":"Inhaled corticosteroids and the risks of diabetes onset and progression","volume":"123","author":"Suissa","year":"2010","journal-title":"Am J Med"},{"key":"B26","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jaip.2018.01.025","article-title":"Inhaled corticosteroids safety and adverse effects in patients with asthma","volume":"6","author":"Heffler","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B27","doi-asserted-by":"crossref","first-page":"446","DOI":"10.2500\/aap.2022.43.220027","article-title":"Dose-dependent association between inhaled corticosteroid use and risk of obesity and metabolic syndrome in asthma","volume":"43","author":"Wangberg","year":"2022","journal-title":"Allergy Asthma Proc"},{"key":"B28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.nutres.2013.12.006","article-title":"A systematic review of the effect of oral glucocorticoids on energy intake, appetite, and body weight in humans","volume":"34","author":"Berthon","year":"2014","journal-title":"Nutr Res"},{"key":"B29","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4168\/aair.2024.16.4.338","article-title":"Comparison of asthma phenotypes in severe asthma cohorts (SARP, U-BIOPRED, ProAR and COREA) from 4 continents","volume":"16","author":"Park","year":"2024","journal-title":"Allergy Asthma Immunol Res"},{"key":"B30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000362196","article-title":"Predictors of weight loss in obese older adults: findings from the USA and the UK","volume":"7","author":"Jackson","year":"2014","journal-title":"Obes Facts"}],"container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2025\/00000046\/00000004\/art00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T04:32:26Z","timestamp":1752553946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2025.46.250041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7,1]]}},"alternative-id":["1088-5412(20250701)46:4L.296;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2025.46.250041","relation":{},"ISSN":["1088-5412"],"issn-type":[{"type":"print","value":"1088-5412"}],"subject":[],"published":{"date-parts":[[2025,7,1]]}}}