{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:26:54Z","timestamp":1759624014702,"version":"build-2065373602"},"reference-count":32,"publisher":"Oceanside Publications Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> Previously, we reported that older women taking increased numbers of cough medications with increased number and frequency of medical encounters and normal or near-normal lung function more likely had unexplained chronic cough (UCC) versus asthma and\/or chronic\n obstructive pulmonary disease. This study sought to identify clinical risk factors that could differentiate UCC from explained chronic cough (ECC).  <jats:bold>Methods:<\/jats:bold> A validated electronic questionnaire was distributed to patients with chronic cough (CC) at seven cough centers throughout\n the United States. The mean \u00b1 standard error, frequencies of continuous variables (one-way analysis), and cross-tabulation frequencies for categorical variables (two-way analysis) were calculated. Univariate comparisons between UCC and ECC were performed by using the t-test and nonparametric\n one-way analysis. Significant determinants of UCC and cough severity were assessed by using multiple logistic regression.  <jats:bold>Results:<\/jats:bold> A total of 150 patients were enrolled, of whom 29 of 150 were classified as having UCC, and 121 of 150 were classified as having ECC. No significant\n differences for family history, age, gender, and race, or seasonality differentiated UCC from ECC. Multiple logistic regression revealed the absence of postnasal drip significantly differentiated UCC from ECC (odds ratio 4.8 [95% Confidence Level, 1.6\u201015.3]). The severity of CC was\n worse for patients with UCC, patients with chronic bronchitis and\/or emphysema, hypertension, ex-smoking history, high body mass index, female gender, education level, and reactivity to more environmental irritants (perfume, p\u2009=\u20090.006; household cleaners, p\u2009=\u20090.01;\n air fresheners, p\u2009=\u20090.03; cold air, p\u2009=\u20090.007; cigarette smoke, p\u2009=\u20090.05).  <jats:bold>Conclusion:<\/jats:bold> Patients with UCC more frequently presented with specific demographic features, comorbid characteristics, and more severe cough induced by environmental\n irritants compared with ECC. These clinical characteristics may be useful for identifying risk factors that can accelerate the diagnosis of UCC.<\/jats:p>","DOI":"10.2500\/aap.2025.46.250065","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:36:17Z","timestamp":1758083777000},"page":"422-430","source":"Crossref","is-referenced-by-count":1,"title":["Multicenter questionnaire study investigating characteristics of adults with unexplained chronic cough versus explained chronic cough"],"prefix":"10.2500","volume":"46","author":[{"given":"Alisa","family":"Gnaensky","sequence":"first","affiliation":[{"name":"From the University of Manchester;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboobeh","family":"Mahdavinia","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Internal Medicine, UT Health Houston, McGovern School of Medicine, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahzad","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Rochester Regional Health;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill A.","family":"Poole","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandel","family":"Sher","sequence":"additional","affiliation":[{"name":"Center for Cough, Largo, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffi","family":"Tachdjian","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California Los Angeles, Los Angeles, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"White","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma and Immunology, Scripps Clinic;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua S.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology. Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umesh","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology. Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology. 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