{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:29:43Z","timestamp":1772821783905,"version":"3.50.1"},"reference-count":24,"publisher":"Oceanside Publications Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Common variable immunodeficiency (CVID) and selective immunoglobulin G (IgG) deficiency (sIgGD) are primary antibody deficiencies with divergent clinical trajectories. CVID is characterized by recurrent infections and systemic noninfectious complications, whereas\n sIgGD typically follows a milder course. Despite sharing clinical features such as recurrent infections, comparative data on complications and mortality remain limited, which hinders risk-stratified management.\n                    <jats:bold>Objective:<\/jats:bold>\n                    This study compared the prevalence, clinical impact,\n and mortality associated with noninfectious complications in CVID and sIgGD, and identified predictors of adverse outcomes to support risk-stratified management and examined clinical differences within the CVID group based on baseline serum IgM levels.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A single-center\n retrospective cohort study (2018\u20102024) included 111 patients with CVID and 19 patients with sIgGD. Diagnostic criteria for CVID included hypogammaglobulinemia (IgG level &lt; 400 mg\/dL with low IgA\/IgM), impaired vaccine responses, and exclusion of secondary causes. The sIgGD required\n isolated IgG deficiency with normal IgA\/IgM and intact vaccine responses. Noninfectious complications, including organ-specific and systemic manifestations as well as bronchiectasis were evaluated. In patients with CVID, a predefined subgroup analysis was performed based on baseline serum\n IgM levels (normal versus &lt;40 mg\/dL). Multivariate logistic regression identified mortality predictors.\n                    <jats:bold>Results:<\/jats:bold>\n                    The patients with CVID exhibited significantly higher rates of recurrent sinopulmonary infections (70.3% versus 42.1%), bronchiectasis (46.8% versus 21.1%),\n and noninfectious complications (57.7% versus 31.6%), including autoimmune disorders such as hematologic manifestations (33.3% versus 10.5%). In the CVID group, the patients with low IgM levels exhibited a significantly higher prevalence of gastrointestinal involvement (24.0% versus 5.6%;\n p = 0.035). Bronchiectasis (odds ratio [OR] 5.22) and noninfectious complications (OR 7.95) independently predicted mortality in CVID. Male sex showed borderline risk. In contrast, no mortality was observed in the sIgGD cohort over the study period.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    CVID is\n associated with substantial noninfectious morbidity and mortality, which necessitates early identification and long-term monitoring. In contrast, sIgGD exhibits a milder clinical phenotype, although preventive care remains important. These findings support distinct management strategies and\n highlight the utility of clinical markers for risk stratification.\n                  <\/jats:p>","DOI":"10.2500\/aap.2025.46.250077","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T04:32:17Z","timestamp":1761712337000},"page":"498-505","source":"Crossref","is-referenced-by-count":2,"title":["Comparative analysis of demographic and clinical features in common variable immunodeficiency and selective immunoglobulin G deficiency"],"prefix":"10.2500","volume":"46","author":[{"given":"Mehmet Emin","family":"Gerek","sequence":"first","affiliation":[{"name":"From the Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Colkesen","sequence":"additional","affiliation":[{"name":"From the Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tugba","family":"Onalan","sequence":"additional","affiliation":[{"name":"From the Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Arzu","family":"Akkus","sequence":"additional","affiliation":[{"name":"From the Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Kilinc","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Allergy, Batman Training and Research Hospital, Batman, Turkey; 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