{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:10:45Z","timestamp":1787605845400,"version":"build-2736575974"},"reference-count":21,"publisher":"Oceanside Publications Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Allergic march refers to the association of multiple allergic diseases but current understanding primarily focuses on immunoglobulin E (IgE) mediated food allergies (FA) (IgE-FA). The impact of non\u2010IgE-FAs on allergic march remains unclear.\n                    <jats:bold>Objective:<\/jats:bold>\n                    To determine whether food protein\u2010induced allergic proctocolitis (FPIAP), a non\u2010IgE-FA, coexists with other allergic diseases during follow-up and to identify predictive factors.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Eighty-four patients diagnosed with FPIAP who had been followed\n up for at least 3 years and 89 age- and gender-matched controls were compared for the presence of concomitant allergic conditions.\n                    <jats:bold>Results:<\/jats:bold>\n                    Patients with FPIAP who were followed up regularly for at least 3 years were evaluated for the presence of concurrent allergic diseases\n at a median (interquartile range [IQR]) age of 50 months (47\u201054 months), whereas, in the age- and gender-matched control group, the median (IQR) age at evaluation was 51 months (47.5\u201057.5 months). Asthma, allergic rhinitis (AR), and IgE-FA rates in the FPIAP group were 29.8%\n (n = 25), 29.8% (n = 25), and 15.5% (n = 13), respectively, compared with 14.6% (n = 13), 13.5% (n = 12), and 3.4% (n = 3), respectively, in the control group. Asthma, AR, and IgE-FA were significantly more frequent in the FPIAP group (p = 0.03, p = 0.02, p = 0.01, respectively). Atopic dermatitis\n in those under the age of 2 years was more prevalent in the FPIAP group (38.6%, [n = 32]) compared with the controls (10.6% [n = 9]) (p = 0.001). Although vomiting at onset was identified as a predictive factor for asthma, maternal rhinitis and delayed introduction of complementary feeding\n were associated with an increased risk of developing AR in the FPIAP group.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    This study demonstrated a higher rate of asthma, AR, and IgE-FA in patients with FPIAP compared with age- and gender-matched controls. These findings emphasize the importance of increasing\n awareness of the potential coexistence of FPIAP with other allergic diseases.\n                  <\/jats:p>","DOI":"10.2500\/aap.2026.47.250088","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T04:32:26Z","timestamp":1768019546000},"page":"61-69","source":"Crossref","is-referenced-by-count":2,"title":["Is atopic comorbidity increased in proctocolitis?"],"prefix":"10.2500","volume":"47","author":[{"given":"Nagihan","family":"Iskender","sequence":"first","affiliation":[{"name":"From the Division of Pediatric Allergy and Immunology, Kocaeli University Faculty of Medicine, Kocaeli, T\u00fcrkiye;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Ozanli","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Allergy and Immunology, Kocaeli University Faculty of Medicine, Kocaeli, 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