{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:08:00Z","timestamp":1788206880966,"version":"build-2803163510"},"reference-count":29,"publisher":"Oceanside Publications Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"\n Background:<\/jats:bold>\n Hazelnut and sesame are among the leading causes of immunoglobulin E mediated food allergies in the eastern Mediterranean region. Notably, initial allergic reactions often occur on the first known oral exposure, which suggests a potential role of non-oral routes\n of sensitization, including environmental exposure.\n Objectives:<\/jats:bold>\n The study aimed to investigate the presence of environmental hazelnut and sesame allergens.\n Methods:<\/jats:bold>\n House dust samples were collected from the homes of children newly diagnosed, previously\n diagnosed, and nonallergic (control) with or without hazelnut or sesame allergy.\n Results:<\/jats:bold>\n A total of 57 and 63 house dust samples were analyzed for hazelnut and sesame allergens, respectively. In the hazelnut allergy group, newly diagnosed patients had a significantly higher\n rate of detectable hazelnut antigen (53%) compared with both previously diagnosed (20%) and control (15%) groups (p\u2009<\u20090.001 for both comparisons). Moreover, the amount of hazelnut antigen was higher in the newly diagnosed group compared with controls (median [interquartile\n range {IQR}] 0.1 \u00b5g\/mL [0\u20100.8 \u00b5g\/mL] versus 0.0 \u00b5g\/mL [0\u20100 \u00b5g\/mL]; p\u2009<\u20090.001). For sesame allergy, the previously diagnosed group had lower rates of detectable antigen (55%) compared with the newly diagnosed (74%) and control (100%) groups\n (p\u2009<\u20090.001 for both). In addition, the quantity of sesame antigen was higher in the control group compared with the previously diagnosed group (median [IQR] 1.41 \u00b5g\/mL [0\u20101.085 \u00b5g\/mL] versus 0.39 \u00b5g\/mL [0.882\u20103.645 \u00b5g\/mL]; p\u2009<\u20090.001).\n Notably, within the control homes, sesame antigen was detected more frequently (100% versus 15%) and in greater amounts (median [IQR] 1.21 \u00b5g\/mL [0.88\u20103.64 \u00b5g\/mL] versus 0.0 \u00b5g\/mL [0\u20100 \u00b5g\/mL]) versus hazelnut antigen.\n Conclusion:<\/jats:bold>\n The\n detection of hazelnut and sesame allergens in household dust, particularly at higher rates and quantities in the environments of patients with newly diagnosed allergy, supports the potential role of environmental exposure in the development of these food allergies. Further studies are needed\n to clarify the timing, dose, and clinical relevance of such exposures in sensitization pathways.\n <\/jats:p>","DOI":"10.2500\/aap.2026.47.250093","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T04:32:26Z","timestamp":1768019546000},"page":"47-54","source":"Crossref","is-referenced-by-count":3,"title":["House dust allergens of children with newly diagnosed hazelnut or sesame allergy"],"prefix":"10.2500","volume":"47","author":[{"given":"Ozan","family":"Hakverdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melike","family":"Ocak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umit Murat","family":"Sahiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Soyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulent Enis","family":"Sekerel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jaci.2017.11.005","article-title":"Mechanisms of food allergy","volume":"141","author":"Sampson","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"B2","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.jaci.2012.02.036","article-title":"Update on risk factors for food allergy","volume":"129","author":"Lack","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"B3","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1542\/peds.101.3.e8","article-title":"Prevalence of IgE-mediated food allergy among children with atopic dermatitis","volume":"101","author":"Eigenmann","year":"1998","journal-title":"Pediatrics"},{"key":"B4","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1111\/bjd.15747","article-title":"A randomized trial of a barrier lipid replacement strategy for the prevention of atopic dermatitis and allergic sensitization: the PEBBLES pilot study","volume":"178","author":"Lowe","year":"2018","journal-title":"Br J Dermatol"},{"key":"B5","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.jaci.2021.10.018","article-title":"Food allergy across the globe","volume":"148","author":"Sampath","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"B6","doi-asserted-by":"crossref","first-page":"554","DOI":"10.24953\/turkjped.2021.04.002","article-title":"IgE mediated food allergy in Turkey: different spectrum, similar outcome","volume":"63","author":"Akarsu","year":"2021","journal-title":"Turk J Pediatr"},{"key":"B7","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/pai.13320","article-title":"Food-induced anaphylaxis in infants, as compared to toddlers and preschool children in Turkey","volume":"31","author":"Kahveci","year":"2020","journal-title":"Pediatr Allergy Immunol"},{"key":"B8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000505996","article-title":"Immunoglobulin E-mediated food allergies differ in east Mediterranean children aged 0\u20132 years","volume":"181","author":"Kahveci","year":"2020","journal-title":"Int Arch Allergy Immunol"},{"key":"B9","doi-asserted-by":"crossref","first-page":"742732","DOI":"10.3389\/fimmu.2021.742732","article-title":"From allergen molecules to molecular immunotherapy of nut allergy: a hard nut to crack","volume":"12","author":"Fuhrmann","year":"2021","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jaci.2008.12.014","article-title":"Household peanut consumption as a risk factor for the development of peanut allergy","volume":"123","author":"Fox","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"B11","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jaci.2013.02.034","article-title":"Peanut protein in household dust is related to household peanut consumption and is biologically active","volume":"132","author":"Brough","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B12","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.jaci.2014.08.011","article-title":"Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations","volume":"134","author":"Brough","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"B13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jaci.2014.10.007","article-title":"Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy","volume":"135","author":"Brough","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"B14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/cea.12231","article-title":"Food allergens in mattress dust in Norwegian homes - a potentially important source of allergen exposure","volume":"44","author":"Bertelsen","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"B15","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.jaci.2005.02.038","article-title":"Diagnosing peanut allergy with skin prick and specific IgE testing","volume":"115","author":"Roberts","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"B16","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jaci.2013.05.038","article-title":"Skin prick test responses and allergen-specific IgE levels as predictors of peanut, egg, and sesame allergy in infants","volume":"132","author":"Peters","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jaci.2019.06.049","article-title":"Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence.","volume":"145","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"B18","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jaad.2013.10.010","article-title":"Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis","volume":"70","author":"Eichenfield","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"B19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jaci.2017.02.019","article-title":"The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up","volume":"140","author":"Peters","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B20","article-title":"2023 GINA Main Report - Global Initiative for Asthma"},{"key":"B21","doi-asserted-by":"crossref","first-page":"100122","DOI":"10.1016\/j.waojou.2020.100122","article-title":"Fine-tuning the use of a skin prick test device","volume":"13","author":"Kahveci","year":"2020","journal-title":"World Allergy Organ J"},{"key":"B22","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.jaci.2012.10.017","article-title":"Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report","volume":"130","author":"Sampson","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"B23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.anai.2021.09.005","article-title":"The role of diagnostic tests and oral food challenge results to predict sesame allergy","volume":"128","author":"Ocak","year":"2022","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.alit.2021.10.001","article-title":"Multiplex component-based allergen macroarray test is useful to predict clinical reactivity to tree nuts in children","volume":"71","author":"Akarsu","year":"2022","journal-title":"Allergol Int"},{"key":"B25","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.jaci.2021.12.789","article-title":"Updating the CoFAR grading scale for systemic allergic reactions in food allergy","volume":"149","author":"Chinthrajah","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"B26","doi-asserted-by":"crossref","first-page":"2601060231170250","DOI":"10.1177\/02601060231170250","article-title":"Characteristics of tree nut, peanut, and seed consumption in the eastern Mediterranean region","author":"Parlak","year":"2023","journal-title":"Nutr Health"},{"key":"B27","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.aller.2019.07.005","article-title":"Phenotypical characterization of tree nuts and peanut allergies in east Mediterranean children","volume":"48","author":"Cetinkaya","year":"2020","journal-title":"Allergol Immunopathol (Madr)"},{"key":"B28","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1056\/NEJMoa1414850","article-title":"Randomized trial of peanut consumption in infants at risk for peanut allergy","volume":"372","author":"Du Toit","year":"2015","journal-title":"N Engl J Med"},{"key":"B29","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1111\/all.15418","article-title":"Food allergy, mechanisms, diagnosis and treatment: innovation through a multi-targeted approach","volume":"77","author":"Sindher","year":"2022","journal-title":"Allergy"}],"container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2026\/00000047\/00000001\/art00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T04:33:18Z","timestamp":1768019598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2026.47.250093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"alternative-id":["1088-5412(20260101)47:1L.47;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2026.47.250093","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,1]]}}}