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This case highlights the importance of an urticaria history and considerations for a broader evaluation given the clinical characteristics and patient\u2019s age.<\/jats:p>","DOI":"10.2500\/aap.2026.47.250095","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T04:32:26Z","timestamp":1768019546000},"page":"70-73","source":"Crossref","is-referenced-by-count":3,"title":["An infant with chronic relapsing urticaria"],"prefix":"10.2500","volume":"47","author":[{"given":"Candice N.","family":"Gard","sequence":"first","affiliation":[{"name":"From the Division of Allergy and Clinical Immunology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Blase","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee","family":"Speck","sequence":"additional","affiliation":[{"name":"From the Division of Allergy and Clinical Immunology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.jaci.2014.02.036","article-title":"The diagnosis and management of acute and chronic urticaria: 2014 update","volume":"133","author":"Bernstein","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"B2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11882-020-00929-1","article-title":"Chronic urticaria in children: an update on diagnosis and treatment","volume":"20","author":"Wang","year":"2020","journal-title":"Curr Allergy Asthma Rep"},{"key":"B3","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1111\/all.13182","article-title":"Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: a systematic review","volume":"72","author":"Kolkhir","year":"2017","journal-title":"Allergy"},{"key":"B4","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1136\/annrheumdis-2021-221801","article-title":"The 2021 EULAR\/American College of Rheumatology points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases: cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of the interleukin-1 receptor antagonist","volume":"81","author":"Romano","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"B5","first-page":"5","article-title":"Urticaria and urticaria related skin condition\/disease in children","volume":"40","author":"Novembre","year":"2008","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"B6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3389\/fimmu.2018.00369","article-title":"Activated PI3 kinase delta syndrome: from genetics to therapy","volume":"9","author":"Michalovich","year":"2018","journal-title":"Front Immunol"},{"key":"B7","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12016-019-08738-9","article-title":"Clinical, immunological, and genetic features in patients with activated PI3K\u03b4 syndrome (APDS): a systematic review","volume":"59","author":"Jamee","year":"2020","journal-title":"Clin Rev Allergy Immunol"},{"key":"B8","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1016\/j.jaip.2021.07.044","article-title":"Clinical manifestations and outcomes of activated phosphoinositide 3-kinase \u03b4 syndrome from the USIDNET cohort","volume":"9","author":"Oh","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.coi.2021.04.010","article-title":"Infections in activated PI3K delta syndrome (APDS)","volume":"72","author":"Brodsky","year":"2021","journal-title":"Curr Opin Immunol"}],"container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2026\/00000047\/00000001\/art00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T04:33:14Z","timestamp":1768019594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2026.47.250095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"alternative-id":["1088-5412(20260101)47:1L.70;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2026.47.250095","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,1]]}}}