{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:44:47Z","timestamp":1782398687891,"version":"3.54.5"},"reference-count":26,"publisher":"Oceanside Publications Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"\n Background:<\/jats:bold>\n Cow\u2019s milk protein allergy (CMPA) imposes a significant burden on the lives of infants and families and can cause various complications, but there are limited data on the clinical burden associated with infection.\n Objective:<\/jats:bold>\n This study\n aimed to compare infection frequency, antibiotic use, and hospitalization rates between children with CMPA and healthy controls.\n Methods:<\/jats:bold>\n Patients diagnosed with CMPA (IgE-mediated or non-IgE-mediated) in the pediatric allergy-immunology outpatient clinic and healthy infants\n admitted to the social pediatrics outpatient clinic were evaluated prospectively at initial visit, 6 months, and 12 months. Clinical characteristics, history of respiratory, skin, gastrointestinal, and urinary tract infections, antibiotic use, and hospitalization rates were analyzed.\n Results:<\/jats:bold>\n Compared to controls, the CMPA group had significantly lower prevalence and duration of exclusive breastfeeding (p < 0.001 for both) and significantly higher income (p = 0.035), presence of siblings (p < 0.001), household size (p < 0.001), rate of suburban dwelling\n (p = 0.008), and rate of atopic dermatitis (p = 0.003). Rates of infection (all systems), antibiotic use, and hospitalization were higher in the CMPA group compared to controls (p < 0.001 for all) and among patients with IgE-mediated CMPA compared to those with non-IgE-mediated CMPA (p\n < 0.05 for all). Respiratory and skin infections were more common and gastrointestinal infections were less common in IgE-mediated CMPA compared to non-IgE-mediated CMPA (p < 0.001 for all).\n Conclusion:<\/jats:bold>\n CMPA (especially the IgE phenotype) was associated with increased\n infection frequency and severity in infants. These findings suggest the need for a more careful approach to infection risk in patients with CMPA and the importance of disease control.\n <\/jats:p>","DOI":"10.2500\/aap.2026.47.250098","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:35:38Z","timestamp":1773722138000},"page":"e17-e23","source":"Crossref","is-referenced-by-count":2,"title":["Cow\u2019s milk protein allergy: A risk factor for infections in infants?"],"prefix":"10.2500","volume":"47","author":[{"given":"Gaye","family":"Kocatepe","sequence":"first","affiliation":[{"name":"From the Pediatric Allergy-Immunology Department, Akdeniz University School of Medicine, Antalya, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara Fatma Kocacik","family":"Uygun","sequence":"additional","affiliation":[{"name":"From the Pediatric Allergy-Immunology Department, Akdeniz University School of Medicine, Antalya, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senay","family":"Ture","sequence":"additional","affiliation":[{"name":"Social Pediatrics Department, Akdeniz University School of Medicine, Antalya, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevtap","family":"Velipasaoglu","sequence":"additional","affiliation":[{"name":"Social Pediatrics Department, Akdeniz University School of Medicine, Antalya, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humeyra","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Public Health Department, Gaziosmanpa\u015fa University School of Medicine, Tokat, Turkey; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mine","family":"Erkan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Akdeniz University School of Medicine, Antalya, 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