{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:45:23Z","timestamp":1782539123276,"version":"3.54.5"},"reference-count":27,"publisher":"Oceanside Publications Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The study was to systematically evaluate the correlation between childhood asthma and obstructive sleep apnea (OSA).\n                    <jats:bold>Methods:<\/jats:bold>\n                    Several medical literature data bases were searched for studies published up to March 2025, by using the keywords\n \u201casthma\u201d and \u201cobstructive sleep apnea\u201d and \u201cchild*.\u201d We included observational studies, children with OSA diagnosed\n                    <jats:italic>via<\/jats:italic>\n                    polysomnography, clinical criteria, or validated tools; and asthma confirmed by physician diagnosis, medication use, or validated\n questionnaires and international code.\n                    <jats:bold>Results:<\/jats:bold>\n                    Eleven studies were included that covered populations in the United States, Europe, and Asia. The pooled odds ratio (OR) for the association between childhood asthma and OSA was 1.66 (95% confidence interval [CI], 1.21\u20102.26;\n p\u2009&lt;\u20090.001). Subgroup analysis by study design showed significant associations in cohort (OR 2.00 [95% CI, 1.35\u20102.96]) and cross-sectional (OR 1.55 [95% CI, 0.69\u20103.44]) but not in case-control studies (OR 0.85 [95% CI, 0.32\u20102.28]). Geographically, the association\n was strongest in America (OR 1.99 [95% CI, 1.35\u20102.96]) and Asia (OR 1.64 [95% CI, 1.19\u20102.25]), with a nonsignificant trend in Europe (OR 0.91 [95% CI, 0.34\u20102.42]). Sensitivity analyses directionally consistent with the results, and Egger\u2019s test (p\u2009=\u2009.587)\n indicated no significant publication bias.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Childhood asthma is significantly associated with an increased risk of OSA, with sleep disorders likely exacerbating this relationship. Integrated screening and management strategies are warranted, particularly in high-risk\n regions such as America and Asia.\n                  <\/jats:p>","DOI":"10.2500\/aap.2026.47.260014","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:42:02Z","timestamp":1777437722000},"page":"e36-e47","source":"Crossref","is-referenced-by-count":1,"title":["Breathing through the night: A meta-analysis of childhood asthma and obstructive sleep apnea in sleep-disordered contexts"],"prefix":"10.2500","volume":"47","author":[{"given":"Kaiwen","family":"Zheng","sequence":"first","affiliation":[{"name":"From the School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1164\/rccm.201810-1838TR","article-title":"Asthma and obstructive sleep apnea overlap: what has the evidence taught us?","volume":"201","author":"Prasad","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"B2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fped.2019.00246","article-title":"Epidemiology of asthma in children and adults","volume":"7","author":"Dharmage","year":"2019","journal-title":"Front Pediatr"},{"key":"B3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00431-019-03557-8","article-title":"Obstructive sleep apnea in developmental age. A narrative review","volume":"179","author":"Lo Bue","year":"2020","journal-title":"Eur J Pediatr"},{"key":"B4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s40001-023-01097-4","article-title":"The relationship between obstructive sleep apnea and asthma severity and vice versa: a systematic review and meta-analysis","volume":"28","author":"Wang","year":"2023","journal-title":"Eur J Med Res"},{"key":"B5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11325-008-0174-x","article-title":"Obstructive sleep apnea and history of asthma in snoring children","volume":"12","author":"Ramagopal","year":"2008","journal-title":"Sleep Breath"},{"key":"B6","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/ppul.26375","article-title":"Obstructive sleep apnea screening in children with asthma","volume":"58","author":"Sowho","year":"2023","journal-title":"Pediatr Pulmonol"},{"key":"B7","doi-asserted-by":"crossref","first-page":"900216","DOI":"10.3389\/fped.2022.900216","article-title":"Analysis of the risk factors associated with obstructive sleep apnea syndrome in Chinese children","volume":"10","author":"Xiao","year":"2022","journal-title":"Front Pediatr"},{"key":"B8","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.5664\/jcsm.9948","article-title":"Evaluation of obesity and asthma as risk factors for moderate to severe obstructive sleep apnea in children","volume":"18","author":"Ioan","year":"2022","journal-title":"J Clin Sleep Med"},{"key":"B9","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/ppul.25247","article-title":"Impact of obstructive sleep apnea on assisted ventilation in children with asthma exacerbation","volume":"56","author":"Tsou","year":"2021","journal-title":"Pediatr Pulmonol"},{"key":"B10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.anai.2019.11.002","article-title":"Association of obstructive sleep apnea with severity of patients hospitalized for acute asthma","volume":"124","author":"Oka","year":"2020","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B11","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/lary.28029","article-title":"Asthma and obesity as predictors of severe obstructive sleep apnea in an adolescent pediatric population","volume":"130","author":"Narayanan","year":"2020","journal-title":"Laryngoscope"},{"key":"B12","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00405-019-05290-2","article-title":"Obstructive sleep apnea in children and adolescents with and without obesity","volume":"276","author":"Andersen","year":"2019","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"B13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12931-015-0215-5","article-title":"Sleep-disordered breathing and asthma: evidence from a large multicentric epidemiological study in China","volume":"16","author":"Li","year":"2015","journal-title":"Respir Res"},{"key":"B14","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3109\/02770900903229636","article-title":"Asthma as a predictor of obstructive sleep apnea in urban African-American children","volume":"46","author":"Ramagopal","year":"2009","journal-title":"J Asthma"},{"key":"B15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ppul.20179","article-title":"Prevalence of obstructive sleep apnea syndrome and associated symptoms in 3\u201311-year-old Turkish children","volume":"39","author":"Sogut","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"B16","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.3390\/ijerph19095473","article-title":"OSA and chronic respiratory disease: mechanisms and epidemiology","volume":"19","author":"Locke","year":"2022","journal-title":"Inte J Environ Res Public Health"},{"key":"B17","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2310\/JIM.0000000000000065","article-title":"Asthma and obstructive sleep apnea: clinical and pathogenic interactions","volume":"62","author":"Puthalapattu","year":"2014","journal-title":"J Investig Med"},{"key":"B18","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1055\/s-0034-1390023","article-title":"Obstructive sleep apnea: role of intermittent hypoxia and inflammation","volume":"35","author":"May","year":"2014","journal-title":"Semin Respir Crit Care Med"},{"key":"B19","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1164\/ajrccm.162.2.9908058","article-title":"Sleep architecture and respiratory disturbances in children with obstructive sleep apnea","volume":"162","author":"Goh","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"B20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jsmc.2024.02.006","article-title":"Contribution of obstructive sleep apnea to asthmatic airway inflammation and impact of its treatment on the course of asthma","volume":"19","author":"Ioachimescu","year":"2024","journal-title":"Sleep Med Clin"},{"key":"B21","article-title":"HPA axis and sleep","volume-title":"Endotext","author":"Nicolaides","year":"2000"},{"key":"B22","doi-asserted-by":"crossref","first-page":"134202","DOI":"10.1155\/2012\/134202","article-title":"Childhood obesity and obstructive sleep apnea","volume":"2012","author":"Narang","year":"2012","journal-title":"J Nutr Metab"},{"key":"B23","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2147\/NSS.S275252","article-title":"A review of current tools used for evaluating the severity of obstructive sleep apnea","volume":"12","author":"Cao","year":"2020","journal-title":"Nat Sci Sleep"},{"key":"B24","doi-asserted-by":"crossref","first-page":"e13712","DOI":"10.1111\/obr.13712","article-title":"Screening for obstructive sleep apnea (OSA) in children and adolescents with obesity: a scoping review of national and international pediatric obesity and pediatric OSA management guidelines","volume":"25","author":"Ng","year":"2024","journal-title":"Obes Rev"},{"key":"B25","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1542\/peds.109.4.704","article-title":"Clinical practice guideline: diagnosis and management of childhood obstructive sleep apnea syndrome","volume":"109","year":"2002","journal-title":"Pediatrics"},{"key":"B26","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1080\/17476348.2024.2304065","article-title":"Co-existence of OSA and respiratory diseases and the influence of gender","volume":"17","author":"Schiza","year":"2023","journal-title":"Expert Rev Respir Med"},{"key":"B27","doi-asserted-by":"crossref","first-page":"zsad060","DOI":"10.1093\/sleep\/zsad060","article-title":"Pediatric sleep: current knowledge, gaps, and opportunities for the future","volume":"46","author":"Reynolds","year":"2023","journal-title":"Sleep"}],"container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2026\/00000047\/00000003\/art00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:45:32Z","timestamp":1782535532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2026.47.260014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["1088-5412(20260501)47:3L.36;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2026.47.260014","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,1]]}}}