{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:53:40Z","timestamp":1782885220663,"version":"3.54.5"},"reference-count":24,"publisher":"Oceanside Publications Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"\n Background:<\/jats:bold>\n Pumpkin seed allergy is a rare but potentially severe immunoglobulin E (IgE) mediated food allergy, with limited pediatric data and few documented cases worldwide.\n Objective:<\/jats:bold>\n To describe the clinical and diagnostic characteristics of pediatric\n pumpkin seed allergy and to synthesize all previously reported cases through a systematically searched narrative review.\n Methods:<\/jats:bold>\n We retrospectively reviewed the records of children diagnosed with IgE-mediated pumpkin seed allergy at a tertiary pediatric allergy clinic\n in Turkey (2016\u20102024). The diagnosis relied on the clinical history, specific IgE (sIgE), and skin-prick tests (SPT); patients in select cases had oral food challenges. Data on clinical presentation, comorbidities, co-allergies, and laboratory findings were extracted. A structured literature\n search of medical literature data bases identified all published cases of patients with pumpkin seed allergy, which were qualitatively reviewed.\n Results:<\/jats:bold>\n Twenty-five children (76% boys) were identified, with a median diagnosis age of 2.98 years. Immediate reactions were\n universal, and anaphylaxis occurred in 64%. The median SPT wheal was 13 mm, and the median sIgE level was 10.3 kUA\/L. Atopic comorbidities were frequent (atopic dermatitis, 92%; asthma, 48%). Co-allergy was common (tree nuts, 76%; other seeds, 72%); watermelon seed sensitization occurred in\n 83%, with six patients experiencing clinical reactions after watermelon seed ingestion. Pumpkin pulp was tolerated in all the patients. A literature review revealed 14 previously published cases, mostly adults, with 57% experiencing anaphylaxis.\n Conclusion:<\/jats:bold>\n Pumpkin seed\n allergy, although uncommon, frequently causes systemic reactions in children. Our case series underscores the need for clinician awareness, diagnostic inclusion of pumpkin seed in high-consumption regions, and further research into its molecular allergens and cross-reactivity.\n <\/jats:p>","DOI":"10.2500\/aap.2026.47.260028","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:30:30Z","timestamp":1782361830000},"page":"e50-e56","source":"Crossref","is-referenced-by-count":1,"title":["Immunoglobulin E\u2010mediated pumpkin seed allergy in children: Case series and narrative review with a structured literature search"],"prefix":"10.2500","volume":"47","author":[{"given":"Bilge","family":"Acikalin","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melike","family":"Ocak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulent Enis","family":"Sekerel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"12223","DOI":"10.1073\/pnas.0604335103","article-title":"Eastern North America as an independent center of plant domestication","volume":"103","author":"Smith","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.gaost.2023.12.002","article-title":"Pumpkin seeds as nutraceutical and functional food ingredient for future: a review","volume":"7","author":"Singh","year":"2024","journal-title":"Grain Oil Sci Technol"},{"issue":"2 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