{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T17:30:11Z","timestamp":1792949411016,"version":"4.5.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Rhinology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"\n Background<\/jats:title>\n This study analyzes the impact of Staphylococcus aureus enterotoxins (SAEs) and the inflammatory pattern in polyps from China.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Nasal tissue was obtained from 27 consecutive bilateral nasal polyps and 15 control patients and assayed for eotaxin, interleukin-5, soluble interleukin-2 receptor, transforming growth factor (TGF) \u03b2\n 1<\/jats:sub>\n , myeloperoxidase, eosinophil cationic protein, total IgE, and specific IgE to SAEs. Activated eosinophils were stained using EG2 antibodies in polyps from Chinese and comparative white patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The number of EG2\n +<\/jats:sup>\n eosinophils was significantly lower in polyps from Chinese patients versus white patients. Chinese polyps showed significantly increased IgE and soluble interleukin-2 receptor versus control samples, whereas TGF-\u03b2\n 1<\/jats:sub>\n was significantly decreased. Ten of 27 samples in the polyp group versus 0 of 15 controls contained SAE-IgE (p < 0.01). TGF-\u03b2\n 1<\/jats:sub>\n was significantly down-regulated in SAE\n +<\/jats:sup>\n samples versus SAE\n -<\/jats:sup>\n samples (p = 0.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Nasal polyps from China are characterized by B- and T-cell activation, a minor eosinophilic inflammation compared with polyps from white subjects, and a decrease in TGF-\u03b2\n 1<\/jats:sub>\n in comparison with control inferior turbinate tissue. One-third of patients with polyps showed an IgE response to SAEs.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.2500\/ajr.2006.20.2887","type":"journal-article","created":{"date-parts":[[2006,8,21]],"date-time":"2006-08-21T05:54:51Z","timestamp":1156139691000},"page":"445-450","source":"Crossref","is-referenced-by-count":95,"title":["Pattern of Inflammation and Impact of Staphylococcus Aureus Enterotoxins in Nasal Polyps from Southern China"],"prefix":"10.1177","volume":"20","author":[{"given":"Nan","family":"Zhang","sequence":"first","affiliation":[{"name":"Ear, Nose, and Throat Department, University Hospital Ghent, Upper Airway Research Laboratory, Ghent, Belgium"},{"name":"Ear, Nose, and Throat Department, The First Affiliated Hospital, Sun Yet-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Holtappels","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Department, University Hospital Ghent, Upper Airway Research Laboratory, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Claeys","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Department, University Hospital Ghent, Upper Airway Research Laboratory, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganquan","family":"Huang","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Department, The First Affiliated Hospital, Sun Yet-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"van Cauwenberge","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Department, University Hospital Ghent, Upper Airway Research Laboratory, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Bachert","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Department, University Hospital Ghent, Upper 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