{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T07:36:41Z","timestamp":1780817801715,"version":"3.54.1"},"reference-count":18,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Rhinology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tissue remodeling is an important characteristic of nasal polyps (NPs). However, the mechanisms underlying the remodeling processes are poorly defined. This study investigated the role of transforming growth factor (TGF) \u03b21 and eosinophils in the expression of tenascin C (Tn-C), an extracellular matrix glycoprotein, in NPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The protein expression of Tn-C and TGF-\u03b21 was examined by means of immunohistochemistry in NPs and normal control inferior turbinate tissues. Furthermore, cell culture, quantitative RT-PCR, and in situ immunocytofluorescence techniques were used to investigate the direct effect of TGF-\u03b21 and eosinophils on Tn-C production in primary nasal epithelial cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tn-C protein expression was significantly up-regulated in NP tissues and correlated with TGF-\u03b21\n                      <jats:sup>+<\/jats:sup>\n                      eosinophils. TGF-\u03b21 and eosinophils dramatically induced Tn-C mRNA and protein expression in nasal epithelial cells. The effect of eosinophils could be inhibited partly by a neutralizing antibody to TGF-\u03b21.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Eosinophil-derived TGF-\u03b21 may contribute, at least in part, to the tissue remodeling in NPs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajr.2006.20.2918","type":"journal-article","created":{"date-parts":[[2006,12,31]],"date-time":"2006-12-31T18:27:48Z","timestamp":1167589668000},"page":"629-633","source":"Crossref","is-referenced-by-count":19,"title":["The Up-Regulated Expression of Tenascin C in Human Nasal Polyp Tissues is Related to Eosinophil-Derived Transforming Growth Factor \u03b21"],"prefix":"10.1177","volume":"20","author":[{"given":"Zheng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixue","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,11,1]]},"reference":[{"key":"bibr1-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200310000-00027"},{"key":"bibr2-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9812110"},{"key":"bibr3-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90070-8"},{"key":"bibr4-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115764"},{"key":"bibr5-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1007\/BF02896790"},{"key":"bibr6-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041590320"},{"key":"bibr7-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.01.026"},{"key":"bibr8-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.20.4.3265"},{"key":"bibr9-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3796"},{"key":"bibr10-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.04.052"},{"key":"bibr11-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"bibr12-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509133351"},{"key":"bibr13-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.3.9610084"},{"key":"bibr14-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.2500\/105065800781329573"},{"key":"bibr15-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200301000-00022"},{"key":"bibr16-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00019-7"},{"key":"bibr17-ajr.2006.20.2918","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.133.4.921"},{"key":"bibr18-ajr.2006.20.2918","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jcp.1041550119","volume":"155","author":"Davidson 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