{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:27:48Z","timestamp":1777386468626,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Rhinology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The goal of this study was to evaluate the use of the autogenous mesenchymal stem cells (MSCs) impregnated in an injectable alginate gel containing platelet-rich plasma (PRP) for nasal augmentation in rabbit model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Bone marrow\u2013derived MSCs were isolated and expanded from New Zealand white rabbits. At confluence, the cells were mixed with sodium alginate solution. PRP was prepared from the rabbits and it was immediately mixed into the alginate\u2013cell mixture. The cell\u2013PRP\u2013alginate mix was injected into a subcutaneous nasal area. Eight weeks after injection changes in facial contour, newly formed nasal hump was analyzed and the amount of chondroitin sulfate in tissue was measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Augmented nasal dorsa maintained their original shape until harvest. Immunohistochemical staining revealed that the deposited matrix was composed of type II collagen and that it was distributed abundantly and widely in the connective tissue of the tissue generated. The amount of chondroitin sulfate (main component of the proteoglycan in cartilage) produced was significantly higher when MSCs and PRP-alginate were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Injectable PRP-alginate gel containing autologous mesenchymal stem cells may offer a useful means of facial soft tissue augmentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajr.2006.20.2926","type":"journal-article","created":{"date-parts":[[2006,10,9]],"date-time":"2006-10-09T19:10:17Z","timestamp":1160421017000},"page":"520-523","source":"Crossref","is-referenced-by-count":9,"title":["Nasal Augmentation using Injectable Alginate and Mesenchymal Stem Cells in the Rabbit"],"prefix":"10.1177","volume":"20","author":[{"given":"Dong-Joon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Yonsei University Wonju College of Medicine, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Hyun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Natural Fiber Science, Kyoungpook National University, Daegu, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo-Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Yonsei University Wonju College of Medicine, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Yonsei University Wonju College of Medicine, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Taek","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Yonsei University Wonju College of Medicine, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"bibr1-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815652"},{"key":"bibr2-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199809020-00052"},{"key":"bibr3-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780070038008"},{"key":"bibr4-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100142495"},{"key":"bibr5-ajr.2006.20.2926","first-page":"38","volume":"24","author":"Gubisch W.","year":"1992","journal-title":"Handchir Mikrochir Plast Chir"},{"key":"bibr6-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.71"},{"key":"bibr7-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"bibr8-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.1003"},{"key":"bibr9-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1089\/ten.1998.4.415"},{"key":"bibr10-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199511000-00024"},{"key":"bibr11-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(92)90363-2"},{"key":"bibr12-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90306-5"},{"key":"bibr13-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(19981205)42:3<347::AID-JBM2>3.0.CO;2-J"},{"key":"bibr14-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.2500\/105065898782102972"},{"key":"bibr15-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010901214"},{"key":"bibr16-ajr.2006.20.2926","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.6.671"}],"container-title":["American Journal of Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajr.2006.20.2926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajr.2006.20.2926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:36:14Z","timestamp":1777368974000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2500\/ajr.2006.20.2926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.2500\/ajr.2006.20.2926"],"URL":"https:\/\/doi.org\/10.2500\/ajr.2006.20.2926","relation":{},"ISSN":["1050-6586","1539-6290"],"issn-type":[{"value":"1050-6586","type":"print"},{"value":"1539-6290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}