{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:27:58Z","timestamp":1777386478779,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Rhinology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although many studies have implicated interleukin (IL)-4 promoter polymorphisms as potential determinants of disease susceptibility, there are no reports on the association between IL-4 promoter polymorphisms and nasal polyps. The aim of this study was to investigate the relationship between an IL-4 promoter polymorphism and nasal polyps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The C-590T promoter polymorphism of the IL-4 gene was genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis in 106 Korean chronic rhinosinusitis patients with or without nasal polyps and 70 healthy Korean subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The frequency of the T allele at position -590 of the IL-4 gene in a Korean population was 0.85, which was significantly higher than those of other ethnic groups, and the T\/T allele at position -590 of IL-4 was associated with protection against nasal polyps if compared with the C\/C allele (relative risk, 0.529; 95% confidence interval, 0.307\u20130.912; p = 0.028).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>T-590, which is dominant at position -590 of the IL-4 promoter, appears to be associated with a protective mechanism against nasal polyps in Korean populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajr.2006.20.2936","type":"journal-article","created":{"date-parts":[[2006,10,9]],"date-time":"2006-10-09T19:10:17Z","timestamp":1160421017000},"page":"550-553","source":"Crossref","is-referenced-by-count":25,"title":["Interleukin-4 C-590T Polymorphism is associated with Protection against Nasal Polyps in a Korean Population"],"prefix":"10.1177","volume":"20","author":[{"given":"Sung Su","family":"Yea","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Inje University College of Medicine, Busan, Korea"},{"name":"Biohealth Product Research Center, Inje University College of Medicine, Busan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Il","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Inje University College of Medicine, Busan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Kook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Inje University College of Medicine, Busan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Hee","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Inje University College of Medicine, Busan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Seop","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Inje University College of Medicine, Busan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Hyun","family":"Seog","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Inje University College of Medicine, Busan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong-Hong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Inje University College of Medicine, Busan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Ho","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Inje University College of Medicine, Busan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"bibr1-ajr.2006.20.2936","first-page":"1024","volume-title":"Allergy Principles & Practice, Vol. 2.","author":"Slaving 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