{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:05:09Z","timestamp":1777385109053,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glutaredoxins (GRX)-1 is glutathione-dependent oxidoreductase. However, the role of these enzymes remains unknown in airway inflammatory diseases. Therefore, we aimed to establish the expression pattern of GRX-1 in the nasal polyps (NPs) and to assess the regulatory mechanisms associated with GRX-1 expression in interleukin (IL)-1beta-treated airway epithelial cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The expression of GRX-1 in NPs and normal nasal mucosa were analyzed by reverse-transcription polymerase chain reaction and immunohistochemical staining. IL-1beta\u2013induced reactive oxygen species (ROS) formation and GRX-1 expression in the airway epithelial cells was determined by flow cytometry and immunoassay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The expression level of GRX-1 in NPs was significantly higher than in the normal nasal mucosa (p &lt; 0.05). GRX-1 was highly expressed in the surface epithelial cells and the submucosal glandular cells in the NPs. IL-1beta increased the intracellular ROS formation and GRX-1 expression in airway epithelial cells. The inhibition of IL-1beta\u2013induced ROS production by N-acetyl-cystein, an ROS scavenger, reduced GRX-1 expression. Diphenyleneiodonium and apocynin, NADPH oxidase inhibitors, did not abolish IL-1beta\u2013induced ROS ormation and GRX-1 expression, whereas budesonide attenuated it.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High GRX-1 expression in NPs might be a primary de ense against chronic in lammatory oxidative stress in nasal mucosa. IL-1beta\u2013induced up-regulation o GRX-1 in airway epithelial cells is probably mediated by ROS. Glucocorticoids can regulate IL-1beta\u2013induced ROS ormation and GRX-1 expression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2009.23.3318","type":"journal-article","created":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T20:34:00Z","timestamp":1265834040000},"page":"288-293","source":"Crossref","is-referenced-by-count":10,"title":["Expression of Glutaredoxin-1 in Nasal Polyps and Airway Epithelial Cells"],"prefix":"10.1177","volume":"23","author":[{"given":"Hyun-Jae","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Gumi CHA Hospital, College of Medicine, CHA University, Gumi, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Hoon","family":"Bae","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology\u2013Head and Neck Surgery, Yeungnam University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Youn","family":"Song","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology\u2013Head and Neck Surgery, Yeungnam University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Woon","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Physiology, College of Medicine, Yeungnam University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heung-Man","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, College of Medicine, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Dae","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology\u2013Head and Neck Surgery, Yeungnam University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,5,1]]},"reference":[{"key":"bibr1-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.087"},{"key":"bibr2-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.1.152"},{"key":"bibr3-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.04.009"},{"key":"bibr4-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0259RC"},{"key":"bibr5-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2968"},{"key":"bibr6-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3162"},{"key":"bibr7-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1159\/000236724"},{"key":"bibr8-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1023\/B:CBTO.0000003730.21261.fa"},{"key":"bibr9-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1159\/000074047"},{"key":"bibr10-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00389.2003"},{"key":"bibr11-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.115086"},{"key":"bibr12-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200407000-00013"},{"key":"bibr13-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01323.x"},{"key":"bibr14-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1303"},{"key":"bibr15-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510029293"},{"key":"bibr16-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408932102"},{"key":"bibr17-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2007.06.013"},{"key":"bibr18-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3107"},{"key":"bibr19-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1007\/s11120-006-9096-2"},{"key":"bibr20-ajra.2009.23.3318","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.06.014"}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2009.23.3318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2500\/ajra.2009.23.3318","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2009.23.3318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:32:13Z","timestamp":1777368733000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2500\/ajra.2009.23.3318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.2500\/ajra.2009.23.3318"],"URL":"https:\/\/doi.org\/10.2500\/ajra.2009.23.3318","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}