{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:05:22Z","timestamp":1777385122869,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>No standardized medical therapy for chronic rhinosinusitis (CRS) is universally accepted. Success of medical therapy is reportedly 50% to 88%, but studies differ in inclusion criteria, medications, duration of therapy, and defining \u201csuccess.\u201d The objectives of this study were to determine efficacy of a standardized targeted medical therapy (TMT) regimen in CRS and to analyze factors associated with failure of therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of prospectively collected data was performed. CRS was diagnosed based on CRS Taskforce guidelines. TMT was defined as a minimum 4-week treatment with oral antibiotics, oral steroids, topical nasal steroids, topical nasal decongestant rotation, and saline nasal douching. \u201cFailure\u201d was defined as relapse\/persistence of signs\/symptoms or need for surgery. One hundred forty-five patients that received TMT, with a minimum 2-month follow-up, were identified. The results of therapy were reviewed to determine efficacy and analyze factors associated with failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy-four patients (51.03%) were successfully treated. Failures included 26 patients (17.8%) with only partial improvement and 45 (31.03%) who underwent surgery. Only history of facial pressure\/pain (p = 0.049), presence of mucosal inflammation (p = 0.013), and higher endoscopic severity grade (p = 0.011) were associated with failure of TMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TMT was unequivocally successful in 51% of patients. Failures included 31% who underwent surgery and 18% with partial benefit. Surgery was avoided in 69%. Facial pressure\/pain, mucosal inflammation, and higher endoscopic severity grade were associated with failure of medical therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2009.23.3334","type":"journal-article","created":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T20:34:00Z","timestamp":1265834040000},"page":"396-400","source":"Crossref","is-referenced-by-count":70,"title":["Efficacy of Targeted Medical Therapy in Chronic Rhinosinusitis, and Predictors of Failure"],"prefix":"10.1177","volume":"23","author":[{"given":"Devyani","family":"Lal","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Scianna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Stankiewicz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,7,1]]},"reference":[{"key":"bibr1-ajra.2009.23.3334","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.3.260"},{"key":"bibr2-ajra.2009.23.3334","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000214"},{"key":"bibr3-ajra.2009.23.3334","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3047"},{"key":"bibr4-ajra.2009.23.3334","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.07.003"},{"key":"bibr5-ajra.2009.23.3334","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"key":"bibr6-ajra.2009.23.3334","doi-asserted-by":"publisher","DOI":"10.1177\/194589240201600605"},{"key":"bibr7-ajra.2009.23.3334","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2960"}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2009.23.3334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2500\/ajra.2009.23.3334","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2009.23.3334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:32:16Z","timestamp":1777368736000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2500\/ajra.2009.23.3334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.2500\/ajra.2009.23.3334"],"URL":"https:\/\/doi.org\/10.2500\/ajra.2009.23.3334","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}