{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:25:25Z","timestamp":1791851125640,"version":"4.3.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Wegener's granulomatosis (WG), an autoimmune disease, is intimately associated with the sinonasal tract, with involvement reported in 85% of patients during the course of the disease process. The objective of this study was (1) to describe Lund-Mackay (L-M) scores, (2) to delineate patterns of neo-osteogenesis and bony erosion, and (3) to analyze the impact of surgery on the computed tomography (CT) findings of WG patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review was performed on 74 patients with WG presenting to a tertiary care referral center. CT analysis was performed and graded by two independent reviewers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age was 53 years with a male\/female ratio of 0.6:1. The average L-M score was 10.0. Neo-osteogenesis was evident in 78% of the patients with overall average neo-osteogenesis score of 4.2 (range, 0\u201316). Bony erosion was noted on imaging in 62% of patients with overall average score for bony erosion of 2.0 (range, 0\u20138). Patients having undergone previous sinus surgery compared with no previous surgery had statistically significant elevation of overall L-M, bony erosion, and neo-osteogenesis scores (p = 0.024, 0.0009, and 0.0015, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CT imaging in WG patients shows elevated L-M scores and evidence of bony erosion and neo-osteogenesis. Furthermore, surgical manipulation in WG patients is associated with increased bony abnormalities and greater elevations of L-M scores, possibly because of worsening vasculitis and\/or inflammation. The presence of concurrent neo-osteogenesis and bony destruction of the paranasal sinuses should raise clinical suspicion of WG in patients presenting with symptoms of chronic rhinosinusitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2009.23.3359","type":"journal-article","created":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T20:34:00Z","timestamp":1265834040000},"page":"497-501","source":"Crossref","is-referenced-by-count":43,"title":["Computed Tomography Findings in Sinonasal Wegener's Granulomatosis"],"prefix":"10.1177","volume":"23","author":[{"given":"David","family":"Grindler","sequence":"first","affiliation":[{"name":"School of Medicine, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Cannady","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Oregon Health and Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete S.","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,9,1]]},"reference":[{"key":"bibr1-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198009000-00005"},{"key":"bibr2-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91147-X"},{"key":"bibr3-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.02.030"},{"key":"bibr4-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-1-76"},{"key":"bibr5-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9182-2_49"},{"key":"bibr6-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6696.419"},{"key":"bibr7-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200005)43:5<1021::AID-ANR10>3.0.CO;2-J"},{"key":"bibr8-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198302000-00020"},{"key":"bibr9-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197412000-00002"},{"key":"bibr10-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.144.3.7100468"},{"key":"bibr11-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1986.tb00128.x"},{"key":"bibr12-ajra.2009.23.3359","first-page":"134","volume":"66","author":"Simmons J.T.","year":"1987","journal-title":"Ear Nose Throat J"},{"key":"bibr13-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050206"},{"key":"bibr14-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1097\/01.rct.0000191134.67674.c6"},{"key":"bibr15-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-002-0885-9"},{"key":"bibr16-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.2500\/105065801781543763"},{"key":"bibr17-ajra.2009.23.3359","first-page":"183","volume":"31","author":"Lund V.J.","year":"1993","journal-title":"Rhinology"},{"key":"bibr18-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"bibr19-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1258\/002221502760132737"},{"key":"bibr20-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.2500\/105065801779954148"},{"key":"bibr21-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200211000-00008"},{"key":"bibr22-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.04.005"},{"key":"bibr23-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2857"},{"key":"bibr24-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199804000-00008"},{"key":"bibr25-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3222"},{"key":"bibr26-ajra.2009.23.3359","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20161"}],"container-title":["American Journal of Rhinology &amp; 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