{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:06:03Z","timestamp":1777385163479,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Expression of matrix metalloproteinase (MMP)-9 increases in nasal polyp tissues. However, the impact of MMP-9 genotypes on the development of nasal polyposis (NP) is unknown. The aim of this study was to examine a potential association of MMP-9 promoter gene polymorphism with the development of NP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective and case\u2013control study was performed on 93 patients with NP and 115 controls without sinonasal disease. Genotypes of MMP-9 (\u20131562C&gt;T) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The frequency of \u2013 1562CT genotype of MMP-9 was significantly high in NP patients with aspirin-induced asthma (p = 0.014). Distribution of T allele was significantly high in NP patients with aspirin-induced asthma (p = 0.013). MMP-9 genotypes were not associated with gender or the presence of atopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, MMP-9 \u2013 1562CT genotype was associated with susceptibility to NP in aspirin-induced asthmatic patients. Because this report is a population-based study, further research should be performed on larger study subjects to reveal the precise role of MMP-9 promoter gene polymorphism in the development of NP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2009.23.3371","type":"journal-article","created":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T20:34:00Z","timestamp":1265834040000},"page":"568-570","source":"Crossref","is-referenced-by-count":17,"title":["Matrix Metalloproteinase-9 Promoter Gene Polymorphism (\u201315620T) in Nasal Polyposis"],"prefix":"10.1177","volume":"23","author":[{"given":"Selim S.","family":"Erbek","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Yurtcu","sequence":"additional","affiliation":[{"name":"Departments of Medical Biology and Genetics, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyra","family":"Erbek","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feride I.","family":"Sahin","sequence":"additional","affiliation":[{"name":"Departments of Medical Genetics, Baskent University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,11,1]]},"reference":[{"key":"bibr1-ajra.2009.23.3371","first-page":"1","volume":"18","author":"European Academy of Allergology and Clinical Immunology.","year":"2005","journal-title":"Rhinol Suppl"},{"key":"bibr2-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.02.048"},{"key":"bibr3-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1258\/0022215054273269"},{"key":"bibr4-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00364.x"},{"key":"bibr5-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3183"},{"key":"bibr6-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.14.1788"},{"key":"bibr7-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03860.x"},{"key":"bibr8-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-003-0441-z"},{"key":"bibr9-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-005-9042-6"},{"key":"bibr10-ajra.2009.23.3371","first-page":"365","volume-title":"Bioinformatics Methods and Protocols: Methods in Molecular Biology.","author":"Rozen S."},{"key":"bibr11-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2005.00516.x"},{"key":"bibr12-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000150674.30237.3f"},{"key":"bibr13-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.17.4.2877"},{"key":"bibr14-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.13508.x"},{"key":"bibr15-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.03.102"},{"key":"bibr16-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.08.007"},{"key":"bibr17-ajra.2009.23.3371","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.06.022"}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2009.23.3371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2500\/ajra.2009.23.3371","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2009.23.3371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:32:24Z","timestamp":1777368744000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2500\/ajra.2009.23.3371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.2500\/ajra.2009.23.3371"],"URL":"https:\/\/doi.org\/10.2500\/ajra.2009.23.3371","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}