{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:59:44Z","timestamp":1792677584430,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Proton (H\n                      <jats:sup>+<\/jats:sup>\n                      ) secretion and the HVCN1 H\n                      <jats:sup>+<\/jats:sup>\n                      channel are part of the innate host defense mechanism of the airways. The objective of this study was to determine H\n                      <jats:sup>+<\/jats:sup>\n                      secretion in asthmatic and nonasthmatic patients with chronic rhinosinusitis (CRS) in freshly excised human sinonasal tissue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Nasal or sinus mucosa from subjects with three different conditions (normal, CRS, and CRS with asthma) was harvested during sinus surgery. The equilibrium pH and the rate of H\n                      <jats:sup>+<\/jats:sup>\n                      secretion were measured in an Ussing chamber using the pH-stat titration technique.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nasal epithelia isolated from subjects with CRS and asthma had a mucosal equilibrium pH = 6.95 (n = 5), which was significantly lower than in normal subjects (7.35 \u00b1 0.21; n = 5) or from subjects with CRS without asthma (7.33 \u00b1 0.15 In = 5). Nasal epithelia from CRS with asthma (n = 5) secreted H\n                      <jats:sup>+<\/jats:sup>\n                      at a rate of 135 \u00b1 46 nmol\u00b7min\n                      <jats:sup>\u20131<\/jats:sup>\n                      \u00b7cm\n                      <jats:sup>\u20132<\/jats:sup>\n                      . This rate was significantly higher compared with normal (73 \u00b1 39 nmol\u00b7min\n                      <jats:sup>\u20131<\/jats:sup>\n                      \u00b7cm\n                      <jats:sup>\u20132<\/jats:sup>\n                      ; n = 8) or CRS without asthma (51 \u00b1 28 nmol\u00b7min\n                      <jats:sup>\u20131<\/jats:sup>\n                      \u00b7cm\n                      <jats:sup>\u20132<\/jats:sup>\n                      ; n = 7). Mucosal addition of the HVCN1 blocker ZnCl\n                      <jats:sub>2<\/jats:sub>\n                      blocked H\n                      <jats:sup>+<\/jats:sup>\n                      secretion by 70% in normal, 53% in CRS without asthma, and by 51% in CRS with asthma. In contrast, measures in sinus tissues were unaffected by the disease condition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Freshly excised human nasal and sinus epithelia secrete acid. Nasal (but not sinus) tissues from asthmatic CRS patients showed lower mucosal pH values and higher rates of H\n                      <jats:sup>+<\/jats:sup>\n                      secretion than CRS and normal subjects. The increased acid secretion might contribute to epithelial injury in CRS patients with asthma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2009.23.3389","type":"journal-article","created":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T20:34:00Z","timestamp":1265834040000},"page":"e10-e13","source":"Crossref","is-referenced-by-count":27,"title":["Proton Secretion in Freshly Excised Sinonasal Mucosa from Asthma and Sinusitis Patients"],"prefix":"10.1177","volume":"23","author":[{"given":"Do-Yeon","family":"Cho","sequence":"first","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology\u2013Head and Neck Surgery, Stanford University School of Medicine, Stanford, California"},{"name":"Children's Hospital Oakland Research Institute, Oakland, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Hajighasemi","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology\u2013Head and Neck Surgery, Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Illek","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Fischer","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,11,1]]},"reference":[{"key":"bibr1-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215217"},{"key":"bibr2-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00369.2001"},{"key":"bibr3-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.11.165111"},{"key":"bibr4-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1983.127.1.39"},{"key":"bibr5-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.5.C1504"},{"key":"bibr6-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200111-068OC"},{"key":"bibr7-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-004-2511-6"},{"key":"bibr8-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32831da87e"},{"key":"bibr9-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.3.9911005"},{"key":"bibr10-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.034"},{"key":"bibr11-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"bibr12-ajra.2009.23.3389","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1164\/ajrccm\/147.4.1056","volume":"147","author":"Guidelines for the evaluation of impairment\/disability in patients with asthma.","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"bibr13-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(96)70018-5"},{"key":"bibr14-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000182825.82910.80"},{"key":"bibr15-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200607-940OC"},{"key":"bibr16-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.2.426"},{"key":"bibr17-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2634339100"},{"key":"bibr18-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00348.2002"},{"key":"bibr19-ajra.2009.23.3389","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/ppul.20717","volume":"42","author":"Fischer H.","year":"2007","journal-title":"Pediatr Pulmonol"},{"key":"bibr20-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404983200"},{"key":"bibr21-ajra.2009.23.3389","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.08.002"}],"container-title":["American Journal of Rhinology &amp; 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