{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:06:34Z","timestamp":1777385194997,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>B-cell responses may play a role in the pathogenesis of nasal polyposis via local IgA and IgE production and activation of eosinophils and mast cells. B-cell attracting chemokines may therefore have relevance in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNPs)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Polyp and inferior turbinate tissues were obtained from CRSwNPs, CRS without NPs (CRSsNPs), and control patients; ELISA and reverse-transcription polymerase chain reaction were used to detect levels of protein and mRNAfor selected B-cell chemokines (B-cell attracting chemokine 1 [CXCL13\/BCA-1\/BLC]), thymus expressed chemokine (CCL25\/TECK), mucosae-associated epithelial chemokine (CCL28\/MEC), stromal cell\u2013derived factor-1alpha (CXCL12\/SDF-1alpha), and selected chemokine receptor genes (CXCR4, CXCR5, and CXCR7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BCA-1 and SDF-1alpha protein levels were significantly increased in polyp tissue compared with turbinate tissue from CRSsNP patients and controls (p &lt; 0.05 and p &lt; 0.01, respectively). Differences in TECK and MEC were not significant. For mRNA, expression of BCA-1 was significantly up-regulated in polyp tissue and levels correlated with CD20 mRNA expression. Additionally, significant up-regulation of mRNA for the SDF-1alpha receptors CXCR7 and CXCR4 was detected in polyps, while there was a trend for up-regulation of the BCA-1 receptor CXCR5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated levels of the BCA-1 and SDF-1alpha and their receptors may account for an increased presence of B cells and their products, contributing to eosinophilic inflammation in patients with CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2010.24.3386","type":"journal-article","created":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T20:34:00Z","timestamp":1265834040000},"page":"11-16","source":"Crossref","is-referenced-by-count":76,"title":["Evaluation of the Presence of B-cell attractant Chemokines in Chronic Rhinosinusitis"],"prefix":"10.1177","volume":"24","author":[{"given":"Monica","family":"Patadia","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Conley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju","family":"Peters","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia A.","family":"Suh","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"},{"name":"Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, 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Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Schleimer","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,1,1]]},"reference":[{"key":"bibr1-ajra.2010.24.3386","first-page":"1","volume":"20","author":"Fokkens W.","year":"2007","journal-title":"Rhinol Suppl"},{"key":"bibr2-ajra.2010.24.3386","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3228"},{"key":"bibr3-ajra.2010.24.3386","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.008"},{"key":"bibr4-ajra.2010.24.3386","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01225.x"},{"key":"bibr5-ajra.2010.24.3386","first-page":"145","volume":"44","author":"Olze 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