{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T01:41:44Z","timestamp":1783993304821,"version":"3.55.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary ciliary dyskinesia (PCD) is a clinically uniform entity, although cilia motility and structure can vary among patients, making diagnosis difficult. Chronic sinusitis, bronchiectasis, sinus hypoplasia, secretory otitis media, and low fertility are common in PCD patients. The aim of this work was to correlate nasal ciliary activity with clinical and structural abnormalities in PCD. A secondary aim was to evaluate the usefulness of high-resolution digital high-speed video (DHSV) in the diagnosis of PCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed nasal mucociliary transport and cilia ultrastructure by electron microscopy and studied nasal ciliary beat frequency (CBF) and beat pattern using high-resolution DHSV imaging in 34 healthy volunteers, 25 individuals with PCD (including 11 with Kartagener's syndrome [KS]with situs inversus), and 27 with secondary ciliary dyskinesia (SCD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nasal mucociliary transport was defective in the PCD and SCD patients. Ciliary immotility was observed in only six KS patients and was correlated with the absence of dynein. We observed a correlation between partial dynein deficiency and an uncoordinated, stiffly vibrating ciliary beat. Cilia activity and structure were normal in the SCD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nasal mucociliary transport showed a sensitivity of 100% for the diagnosis of PCD but has low specificity. High-resolution DHSV imaging has high sensitivity and specificity for the diagnosis of PCD. Video analysis is probably more useful than the study of mucociliary transport and cilia ultrastructure in screening for PCD. The absence of dynein was correlated with ciliary immotility and was more common in KS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2010.24.3448","type":"journal-article","created":{"date-parts":[[2010,6,8]],"date-time":"2010-06-08T20:33:08Z","timestamp":1276029188000},"page":"175-180","source":"Crossref","is-referenced-by-count":42,"title":["Cilia Motility and Structure in Primary and Secondary Ciliary Dyskinesia"],"prefix":"10.1177","volume":"24","author":[{"given":"Miguel","family":"Armengot","sequence":"first","affiliation":[{"name":"Rhinology Unit, General and University Hospital, Medical School, Valencia University, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Milara","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology, Medical School, Valencia University, Valencia, Spain"},{"name":"Research Unit, General and University Hospital, Valencia, Spain"},{"name":"CIBERES, Health Institute Carlos III, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mata","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology, Medical School, Valencia University, Valencia, Spain"},{"name":"Research Unit, General and University Hospital, Valencia, Spain"},{"name":"CIBERES, Health Institute Carlos III, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Carda","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Medical School, Valencia University, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Cortijo","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology, Medical School, Valencia University, Valencia, Spain"},{"name":"Research Unit, General and University Hospital, Valencia, Spain"},{"name":"CIBERES, Health Institute Carlos III, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,5,1]]},"reference":[{"key":"bibr1-ajra.2010.24.3448","first-page":"3943","volume-title":"The Metabolic and Molecular Bases of Inherited Diseases, 7th ed.","author":"Afzelius B.A.","year":"1995"},{"key":"bibr2-ajra.2010.24.3448","first-page":"839","volume":"39","author":"Afzelius B.","year":"1995","journal-title":"What is the connection? 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