{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:07:54Z","timestamp":1777385274448,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many studies were conducted to figure out the relationship between allergic rhinitis (AR) and lower airway diseases. This study was designed to elucidate the clinical parameters that could predict the coexistence of bronchial hyperresponsiveness (BHR) in AR and suggest a guideline for lower airway evaluation in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred seventy-three patients newly diagnosed with AR were evaluated for the lower airway with the methacholine bronchoprovocation test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BHR was more prevalent in patients with nasal polyps (p = 0.01), in patients complaining of moderate to severe symptoms (p = 0.023), with higher serum total IgE levels (p = 0.001), and with blood eosinophil count (p = 0.008). No statistically significant difference was observed between intermittent and persistent AR patients (p = 0.364). Blood eosinophil count that could predict BHR was calculated as 320 cells\/\u03bcL (p = 0.004).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Instead of a routine lower airway evaluation for all AR patients, we recommend lower airway evaluation for the selected patients with nasal polyps, moderate to severe symptoms, and high blood eosinophil count.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2010.24.3502","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T00:00:21Z","timestamp":1285200021000},"page":"359-363","source":"Crossref","is-referenced-by-count":11,"title":["Nasal Polyps: An Independent Risk Factor for Bronchial Hyperresponsiveness in Patients with Allergic Rhinitis"],"prefix":"10.1177","volume":"24","author":[{"given":"Youngjin","family":"Ahn","sequence":"first","affiliation":[{"name":"Departments of Otorhinolaryngology, Seoul National University Hospital, Seoul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Youn","family":"An","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology, Seoul National University Hospital, Seoul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Bin","family":"Won","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology, Seoul National University Hospital, Seoul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Whun","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology, Seoul National University Hospital, Seoul"},{"name":"Center for Sensory Organ, Seoul National University Medical Research Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology, Seoul National University Hospital, Seoul"},{"name":"Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea"},{"name":"Center for Sensory Organ, Seoul National University Medical Research Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang-Gi","family":"Min","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology, Seoul National University Hospital, Seoul"},{"name":"Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea"},{"name":"Center for Sensory Organ, Seoul National University Medical Research Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Heon","family":"Cho","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Seoul National University Hospital, Seoul"},{"name":"Institute of Allergy and Clinical Immunology, Seoul National University Medical Research 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae-Seo","family":"Rhee","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology, Seoul National University Hospital, Seoul"},{"name":"Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea"},{"name":"Center for Sensory Organ, Seoul National University Medical Research Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,9,1]]},"reference":[{"key":"bibr1-ajra.2010.24.3502","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1983.tb00852.x"},{"key":"bibr2-ajra.2010.24.3502","first-page":"212","volume":"17","author":"Beasly R.","year":"1997","journal-title":"Eur Respir J"},{"key":"bibr3-ajra.2010.24.3502","first-page":"395","volume":"24","author":"Nayak AS.","year":"2003","journal-title":"Allergy Asthma 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