{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:12:40Z","timestamp":1783631560717,"version":"3.55.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fluticasone furoate nasal spray (FFNS), an intranasal corticosteroid, has been shown to be effective in perennial allergic rhinitis in randomized, double-blind, placebo-controlled studies but has been less extensively studied in perennial allergic rhinitis than seasonal allergic rhinitis. This study was designed to evaluate the efficacy and safety of FFNS in perennial allergic rhinitis in adolescents and adults \u226512 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized, double-blind, placebo-controlled, parallel-group study (FFU111439), patients \u226512 years old with perennial allergic rhinitis received FFNS, 110 micrograms (n = 160), or placebo (n = 155) q.d. for 4 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over the entire treatment period, FFNS was significantly (p &lt; 0.05) more effective than placebo with respect to mean changes from baseline in daily reflective total nasal symptoms (primary end point), morning and evening reflective total nasal symptoms, daily reflective individual nasal symptoms, morning predose instantaneous total and individual nasal symptoms, and morning and evening peak nasal inspiratory flow. FFNS did not show a statistically significant difference from placebo in comparisons of ocular symptom measures. Clinically meaningful improvement versus placebo was observed on the Rhinoconjunctivitis Quality of Life Questionnaire with Standardised Activities overall score. Adverse events reported in &gt;3% of patients in a treatment group and reported more frequently with FFNS than placebo were epistaxis (15% FFNS, 8% placebo) and nasopharyngitis (5% FFNS, 1% placebo).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Once-daily FFNS was well tolerated and more effective than placebo at improving nasal symptoms of perennial allergic rhinitis in adolescents and adults \u226512 years of age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2010.24.3534","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T06:20:28Z","timestamp":1291098028000},"page":"444-450","source":"Crossref","is-referenced-by-count":17,"title":["Fluticasone Furoate Nasal Spray is Effective and Well Tolerated for Perennial Allergic Rhinitis in Adolescents and Adults"],"prefix":"10.1177","volume":"24","author":[{"given":"John T.","family":"Given","sequence":"first","affiliation":[{"name":"Allergy & Respiratory Center, Canton, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarjit S.","family":"Cheema","sequence":"additional","affiliation":[{"name":"Alpha Medical Research, Inc., Mississauga, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Dreykluft","sequence":"additional","affiliation":[{"name":"Klinische Forschung, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Stillerman","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, Inc., Plymouth, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MaryJane","family":"Silvey","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil G.","family":"Snowise","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Uxbridge, Middlesex, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Philpot","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"bibr1-ajra.2010.24.3534","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00526.x"},{"key":"bibr2-ajra.2010.24.3534","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63152-3"},{"key":"bibr3-ajra.2010.24.3534","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90349-2"},{"key":"bibr4-ajra.2010.24.3534","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2005.03.002"},{"key":"bibr5-ajra.2010.24.3534","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3280f3c09f"},{"key":"bibr6-ajra.2010.24.3534","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.16.1744"},{"key":"bibr7-ajra.2010.24.3534","doi-asserted-by":"publisher","DOI":"10.3132\/pcrj.2007.00062"},{"key":"bibr8-ajra.2010.24.3534","doi-asserted-by":"publisher","DOI":"10.3132\/pcrj.2007.00015"},{"key":"bibr9-ajra.2010.24.3534","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2007.28.2934"},{"key":"bibr10-ajra.2010.24.3534","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200406000-00005"},{"key":"bibr11-ajra.2010.24.3534","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4733.2003.64231.x"},{"key":"bibr12-ajra.2010.24.3534","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2007.09.001"},{"key":"bibr13-ajra.2010.24.3534","unstructured":"Task Force on Allergic Disorders\u2013American Academy of Allergy, Asthma, and Immunology. 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