{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:06:22Z","timestamp":1788869182285,"version":"build-2803163510"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study was to determine the expression and distribution of angiogenin in nasal polyps and to evaluate the implication of such expression with respect to the development of nasal polyps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Normal inferior turbinate mucosa was obtained from 20 patients undergoing surgery for augmentation rhinoplasty. Nasal polyp samples were obtained from 20 patients undergoing endoscopic sinus surgery for chronic polypoid rhinosinusitis. A semiquantitative reverse transcriptase\u2013polymerase chain reaction (RT-PCR) was performed for angiogenin mRNA. Sections of nasal polyps were immunostained for localization of angiogenin and quantitatively analyzed using computer-based image analysis. Western blot analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Semiquantitative RT-PCR and Western blot analysis showed that angiogenin expression in nasal polyps was increased compared with that in normal nasal mucosa. Using immunohistochemical staining, moderate-to-high levels of angiogenin were mainly localized in the infiltrating inflammatory cells of nasal polyps and faint staining was found in normal nasal mucosa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that angiogenin may play a role in the pathophysiology of nasal polyps.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2011.25.3563","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T01:21:27Z","timestamp":1296436887000},"page":"e23-e26","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Increased Expression of Angiogenin in Nasal Polyps"],"prefix":"10.1177","volume":"25","author":[{"given":"Kyu Sung","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"Medical Devices Clinical Trial Center, Guro Hospital, Korea University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hag","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heung-Man","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery"},{"name":"Medical Devices Clinical Trial Center, Guro Hospital, Korea University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"key":"bibr1-ajra.2011.25.3563","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199206000-00013"},{"key":"bibr2-ajra.2011.25.3563","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199602000-00017"},{"key":"bibr3-ajra.2011.25.3563","first-page":"345","volume":"47","author":"Angiogenin Badet J.","year":"1999","journal-title":"Biological, biochemical and structural properties. 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