{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:09:44Z","timestamp":1777385384702,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nitric oxide (NO), is a biological messenger molecule and a component of innate immunity, with important roles in the regulation of inflammation and in defense against bacterial biofilms. Polymorphisms in genes regulating NO production have the potential for a role in the development of chronic rhinosinusitis (CRS). The purpose of this study was to determine whether polymorphisms in genes regulating NO synthesis are associated with CRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An established population of 206 individuals with severe CRS and 196 postal code\u2013matched controls was previously screened using a pooling genome-wide associations study to estimate allelic frequency. Genes regulating NO synthesis with a maximal probability of association were identified. High-probability single nucleotide polymorphisms SNPs from the NO synthase (NOS1) and its ligand NOS1 adaptor protein (NOS1AP) genes were retained for individual genotyping. PLINK software was used to determine association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen SNPs were genotyped successfully with a genotype distribution in agreement with Hardy-Weinberg equilibrium. Two SNPs for NOS1 (rs1483757 and rs9658281) were significantly associated with CRS, with a protective effect. The severe subphenotype showed stronger associations. Subgroup analysis for the presence of nasal polyps, origin, and gender did not influence strength of associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data suggest that polymorphisms in the NOS1 gene may play a role in the susceptibility to develop CRS. Study findings apply to patients with severe CRS, unresponsive to surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2011.25.3588","type":"journal-article","created":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T09:57:19Z","timestamp":1301306239000},"page":"e49-e54","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Polymorphisms in the nitric oxide synthase 1 gene are associated with severe chronic rhinosinusitis"],"prefix":"10.1177","volume":"25","author":[{"given":"Yuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, H\u00f4tel-Dieu de Montr\u00e9al, Centre de recherche du centre hospitalier de l'Universit\u00e9 de Montreal (CRCHUM), Montreal, QC, Canada"},{"name":"Key Laboratory Otolaryngology Head and Neck Surgery, Ministry of Education of China, Beijing Institute of Otorhinolaryngology, Beijing, PR China"},{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandra Mfuna","family":"Endam","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, H\u00f4tel-Dieu de Montr\u00e9al, Centre de recherche du centre hospitalier de l'Universit\u00e9 de Montreal (CRCHUM), Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelali","family":"Filali-Mouhim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, H\u00f4tel-Dieu de Montr\u00e9al, Centre de recherche du centre hospitalier de l'Universit\u00e9 de Montreal (CRCHUM), Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohan","family":"Boss\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche, H\u00f4pital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Universit\u00e9 Laval, Quebec, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Castano","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, H\u00f4tel-Dieu de Montr\u00e9al, Centre de recherche du centre hospitalier de l'Universit\u00e9 de Montreal (CRCHUM), Montreal, QC, Canada"},{"name":"Centre de Recherche\/Pneumologie, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Desrosiers","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, H\u00f4tel-Dieu de Montr\u00e9al, Centre de recherche du centre hospitalier de l'Universit\u00e9 de Montreal (CRCHUM), Montreal, QC, Canada"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, McGill University, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,3,1]]},"reference":[{"key":"bibr1-ajra.2011.25.3588","first-page":"1","volume":"20","author":"Fokkens W.","year":"2007","journal-title":"Rhinol 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