{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:25:08Z","timestamp":1780385108864,"version":"3.54.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The nasal provocation test (NPT) with lysine aspirin is a useful tool in the diagnosis of aspirin-exacerbated respiratory disease (AERD), previously reffered to as Samter's disease. The aim of the present study focuses on methodological interventions to show the usefulness of the NPT with lysine aspirin in differentiating AERD patients from aspirin-tolerant asthma (ATA) patients to improve the diagnostic efficacy and minimize the risk for adverse reactions compared with the gold standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty AERD patients comprised the active study group while the control group consisted of 25 ATA patients. A combination of objective nasal aerodynamic response (i.e., nasal inspiratory flow and nasal inspiratory resistance) was evaluated by active anterior rhinomanometry and the subjective clinical nasal and extranasal symptoms (including forced expiratory volume) were monitored throughout the challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-five NPTs were successfully completed: sensitivity, 87%; specificity, 100%; positive predictive value, 100%; negative predictive value, 86%; global efficacy, 92.72%. No severe adverse reactions were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present NPT with lysine aspirin proved to be a safe, efficient, and a timesaving method in the diagnosis of patients with AERD, even in those with severe rhinitis\u2013rhinosinusitis and\/or recurrent nasal polyposis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2011.25.3591","type":"journal-article","created":{"date-parts":[[2011,5,30]],"date-time":"2011-05-30T08:34:19Z","timestamp":1306744459000},"page":"166-169","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["The Nose as a Target Organ in the Diagnosis of Severe Aspirin-exacerbated Respiratory Disease"],"prefix":"10.1177","volume":"25","author":[{"given":"Ruperto","family":"Gonz\u00e1lez-P\u00e9rez","sequence":"first","affiliation":[{"name":"Servicio de Alergia, Hospital Universitario N. Sra. La Candelaria, Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Poza-Guedes","sequence":"additional","affiliation":[{"name":"Servicio de Alergia, Hospital Universitario N. Sra. La Candelaria, Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Vives-Conesa","sequence":"additional","affiliation":[{"name":"Servicio de Alergia, Hospital Universitario Doce de Octubre, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"key":"bibr1-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606123142427"},{"key":"bibr2-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.01.034"},{"key":"bibr3-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.016003432.x"},{"key":"bibr4-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02047.x"},{"key":"bibr5-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7437.434"},{"key":"bibr6-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3314"},{"key":"bibr7-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3148"},{"key":"bibr8-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01409.x"},{"key":"bibr9-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00836.x"},{"key":"bibr10-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1159\/000082586"},{"key":"bibr11-ajra.2011.25.3591","first-page":"705","volume":"62","author":"Paul E.","year":"1987","journal-title":"Z Hautkr"},{"key":"bibr12-ajra.2011.25.3591","first-page":"86","volume":"35","author":"Girard J.P.","year":"1969","journal-title":"Clin Immunol Stud Helv Med Acta"},{"key":"bibr13-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70106-5"},{"key":"bibr14-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.suppl_2.S42"},{"key":"bibr15-ajra.2011.25.3591","first-page":"60","volume":"67","author":"Patriarca G.","year":"1991","journal-title":"Ann Allergy"},{"key":"bibr16-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70163-0"},{"key":"bibr17-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.t01-1-13447.x"},{"key":"bibr18-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00025.x"},{"key":"bibr19-ajra.2011.25.3591","first-page":"S76","volume":"7","author":"Dahlen B.","year":"1988","journal-title":"Allergy"},{"key":"bibr20-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90330-8"},{"key":"bibr21-ajra.2011.25.3591","first-page":"61","volume":"71","author":"Melillo G.","year":"1993","journal-title":"Ann Allergy"},{"key":"bibr22-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb01000.x"},{"key":"bibr23-ajra.2011.25.3591","first-page":"55","volume":"18","author":"Clement P.A.R.","year":"1986","journal-title":"Rhinology"},{"key":"bibr24-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1991.tb04355.x"},{"key":"bibr25-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90001-8"},{"key":"bibr26-ajra.2011.25.3591","first-page":"1","volume":"38","author":"Malm L.","year":"2000","journal-title":"Rhinology"},{"key":"bibr27-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.11.921"},{"key":"bibr28-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.6_Pt_1.1616"},{"key":"bibr29-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.039"},{"key":"bibr30-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.011"},{"key":"bibr31-ajra.2011.25.3591","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(02)81955-8"},{"key":"bibr32-ajra.2011.25.3591","unstructured":"Gonz\u00e1lez-P\u00e9rezR. Test de provocaci\u00f3n nasal con acetil-salicilato de lisina: Nuevo m\u00e9todo diagn\u00f3stico en la intolerancia a antiinflamatorios no esteroideos. PhD thesis, Universidad de La Laguna, 122\u2013134, 2004."}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2011.25.3591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2500\/ajra.2011.25.3591","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2011.25.3591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:33:10Z","timestamp":1777368790000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2500\/ajra.2011.25.3591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.2500\/ajra.2011.25.3591"],"URL":"https:\/\/doi.org\/10.2500\/ajra.2011.25.3591","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}