{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:09:56Z","timestamp":1777385396532,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allergic rhinitis is considered a strong risk factor for the onset of asthma. However, few studies addressed this issue from afunctional point of view. The aim of this study was to follow up a group of patients with allergic rhinitis to investigate the onset of possible spirometric abnormalities and\/or bronchial hyperreactivity (BHR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-nine patients with moderate\u2013severe persistent allergic rhinitis were prospectively and consecutively evaluated; 940 controls were also included in the study. Clinical examination, skin-prick test, spirometry, and methacholine challenge were performed in all patients every 2 years for 8 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The number of patients with forced expiratory flow at 25 and 75% of pulmonary volume of&lt;70% of predicted significantly increased during the observation time. At baseline, no subjects had BHR; whereas 34 patients had BHR after 8 years. Sensitization to mites, birch, and Parietaria as well as rhinitis duration are risk factors for these changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the close link between upper and lower airways and suggests that spirometry should be performed in patients with allergic rhinitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2011.25.3607","type":"journal-article","created":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T09:57:19Z","timestamp":1301306239000},"page":"e72-e76","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of Allergic Rhinitis on Bronchi: An 8-year Follow-up Study"],"prefix":"10.1177","volume":"25","author":[{"given":"Giorgio","family":"Ciprandi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino\u2013University of Genoa, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignazio","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Navy Medical Service, La Spezia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Signori","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Genoa University, Genoa, 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