{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:47:26Z","timestamp":1792097246656,"version":"4.4.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interleukin (IL)-17A, mainly produced by Th17 cells, was previously described as an inflammatory cytokine that induces a profile of proinflammatory cytokines, chemokines, and metalloproteinases. Recent studies have revealed that IL-17 is correlated with inflammatory lung disorders by triggering an accumulation of neutrophils. More recently, we have shown that the expression of IL-17 may be involved in the development of nasal polyps (NPs). Here, we describe the characterization of IL-17 expression in patients with chronic rhinosinusitis with nasal polyps (CRSwNPs) from northeast China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Histopathological observations and immunohistochemical (IHC) staining for IL-17, IL-17RD, myeloperoxidase, and CD68 were performed on 52 specimens (42 NPs and 10 specimens of middle turbinate as normal control). Double IHC staining was performed to determine which cells expressed IL-17. The serum expression levels of IL-17 were determined by ELISA and the mRNA expression of IL-17 and Th17 cells transcription factor retinoid acid\u2013related orphan receptor C (RORc) was determined by real-time quantitative polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>42.9% of CRSwNP specimens presented eosinophilic inflammation; 35.7% of CRSwNP specimens presented neutrophilic inflammation. Relatively higher mRNA expression levels of IL-17 and RORc were seen in CRSwNPs compared with the controls. A marked increase of IL-17 and IL-17RD proteins (p &lt; 0.01) were seen in CRSwNP group. The expression levels of IL-17 and RORc did not differ between eosinophilic and noneosinophilic CRSwNPs (p &gt; 0.05). However, high expression levels of IL-17RD were seen in noneosinophilic CRSwNPs compared with eosinophilic CRSwNPs (p &lt; 0.05). The serum expression of IL-17 in CRSwNP patients was similar to healthy controls. The IL-17 expressing cells mainly were the macrophages as shown by double IHC staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Chinese CRSwNP patients showed an enhanced Th17 response regardless of eosinophilic or noneosinophilic inflammation. IL-17 may be involved in the development of NPs through its local immune modulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2011.25.3645","type":"journal-article","created":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T14:27:25Z","timestamp":1317047245000},"page":"e171-e175","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":58,"title":["The Characterization of IL-17A Expression in Patients with Chronic Rhinosinusitis with Nasal Polyps"],"prefix":"10.1177","volume":"25","author":[{"given":"Xiao-Dan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Dong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"key":"bibr1-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01225.x"},{"key":"bibr2-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.2500\/105065800781329573"},{"key":"bibr3-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70333-1"},{"key":"bibr4-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.07.036"},{"key":"bibr5-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2887"},{"key":"bibr6-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.008"},{"key":"bibr7-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.017"},{"key":"bibr8-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90070-5"},{"key":"bibr9-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1038\/ni1261"},{"key":"bibr10-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.02.024"},{"key":"bibr11-ajra.2011.25.3645","first-page":"1","volume":"20","author":"Fokkens W.","year":"2007","journal-title":"Rhinol Suppl"},{"key":"bibr12-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9812110"},{"key":"bibr13-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.2500\/105065899781367537"},{"key":"bibr14-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.018"},{"key":"bibr15-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.6117"},{"key":"bibr16-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2010.05.005"},{"key":"bibr17-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.7.1233"},{"key":"bibr18-ajra.2011.25.3645","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500609"}],"container-title":["American Journal of Rhinology &amp; 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