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CRS with nasal polyp (CRSwNP) is a subtype of CRS, and the pathogenesis of CRSwNP remains largely unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This article reviews the literature regarding the pathophysiology of CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Evidence suggests that altered innate immunity, adaptive immunity, tissue remodeling, and\/or effects of microorganisms may play a role in the development of CRSwNP. Aberrant arachidonic acid metabolism may also contribute to the pathogenesis of CRSwNP in patients with aspirin-exacerbated respiratory disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There have been significant advances in the understanding pathophysiology of CRSwNP. Additional research is needed to elucidate these mechanisms and to determine their relative importance in the pathogenesis of CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2011.25.3680","type":"journal-article","created":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T14:27:25Z","timestamp":1317047245000},"page":"285-290","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":74,"title":["Pathophysiology of Chronic Rhinosinusitis with Nasal Polyp"],"prefix":"10.1177","volume":"25","author":[{"given":"Joy","family":"Hsu","sequence":"first","affiliation":[{"name":"From the Division of Allergy\u2013Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju T.","family":"Peters","sequence":"additional","affiliation":[{"name":"From the Division of Allergy\u2013Immunology, Northwestern University Feinberg 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