{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:13:12Z","timestamp":1785193992038,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis has a major impact on the quality of life of patients with cystic fibrosis (CF) and may contribute to progression of chronic lung disease. Despite multiple sinus surgeries, maxillary sinus involvement is a recurrent problem. The modified endoscopic medial maxillectomy (MEMM) permits debridement in the clinic, improves mucus clearance with nasal irrigations, and increases access for topical delivery of therapeutics. However, clinical outcomes of aggressive sinus surgery with regimented postoperative medical treatment have not been systematically evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CF patients completed the 22-Item Sinonasal Outcome Test questionnaires before sinus surgery (and bilateral MEMM) and at sequential postoperative visits. Objective measures included Lund-Kennedy endoscopic score and pulmonary function tests (forced expiratory volume at 1 second percent [FEV\n                      <jats:sub>1<\/jats:sub>\n                      %] predicted). Culture-directed antibiotic therapy, prednisone, and topical irrigations were initiated postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-two patients (mean age, 26.5 years; 4.9 prior sinus operations) underwent MEMM and sinus surgery. Symptom scores were significantly reduced at 60 days (primary outcome, 64.7 \u00b1 18.4 presurgery versus 27.5 \u00b1 15.3 postsurgery; p &lt; 0.0001) and up to a year postoperatively (27.6 \u00b1 12.6; p &lt; 0.0001). Endoscopic scores were also reduced after surgery (10.4 \u00b1 1.1 presurgery versus 5.7 \u00b1 2.4 [30 days], 5.7 \u00b1 1.4 [60 days], 5.8 \u00b1 1.3 [120 days], and 6.0 \u00b1 1.1 [1 year]; p &lt; 0.0001)]. There were no differences in FEV\n                      <jats:sub>1<\/jats:sub>\n                      % predicted up to 1 year postoperatively, but hospital admissions secondary to pulmonary exacerbations significantly decreased (2.0 \u00b1 1.4 versus 3.2 \u00b1 2.4, respectively; p &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prospective evaluation indicates sinus surgery with MEMM is associated with marked improvement in sinus disease outcomes. Additional studies are necessary to confirm whether this treatment paradigm is associated with improved CF pulmonary disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2012.26.3705","type":"journal-article","created":{"date-parts":[[2012,2,27]],"date-time":"2012-02-27T12:26:34Z","timestamp":1330345594000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":101,"title":["Extensive Surgical and Comprehensive Postoperative Medical Management for Cystic Fibrosis Chronic Rhinosinusitis"],"prefix":"10.1177","volume":"26","author":[{"given":"Frank W.","family":"Virgin","sequence":"first","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B.","family":"Wade","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Gaggar","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Leon","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Randall","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford A.","family":"Woodworth","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"bibr1-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043184"},{"key":"bibr2-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(94)90005-1"},{"key":"bibr3-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1177\/019459988709700403"},{"key":"bibr4-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199608000-00018"},{"key":"bibr5-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(01)00556-0"},{"key":"bibr6-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.1.8025774"},{"key":"bibr7-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890230055011"},{"key":"bibr8-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90183-3"},{"key":"bibr9-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)32650-5"},{"key":"bibr10-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2905"},{"key":"bibr11-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"bibr12-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2009.02.002"},{"key":"bibr13-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"bibr14-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199803000-00005"},{"key":"bibr15-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510410s02"},{"key":"bibr16-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2009.50.5.672"},{"key":"bibr17-ajra.2012.26.3705","first-page":"183","volume":"31","author":"Lund V.J.","year":"1993","journal-title":"Rhinology"},{"key":"bibr18-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000100467.74330.49"},{"key":"bibr19-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2850"},{"key":"bibr20-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.01.027"},{"key":"bibr21-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3248"},{"key":"bibr22-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.1.40"},{"key":"bibr23-ajra.2012.26.3705","first-page":"63","volume":"38","author":"Hadfield P.J.","year":"2000","journal-title":"Rhinology"},{"key":"bibr24-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3189"},{"key":"bibr25-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.12.1097"},{"key":"bibr26-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.5.581"},{"key":"bibr27-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200007000-00023"},{"key":"bibr28-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200102000-00003"},{"key":"bibr29-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63473-4"},{"key":"bibr30-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199802000-00001"},{"key":"bibr31-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199703000-00009"},{"key":"bibr32-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.09.003"},{"key":"bibr33-ajra.2012.26.3705","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.05.034"}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2012.26.3705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2500\/ajra.2012.26.3705","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2012.26.3705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:33:35Z","timestamp":1777368815000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2500\/ajra.2012.26.3705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.2500\/ajra.2012.26.3705"],"URL":"https:\/\/doi.org\/10.2500\/ajra.2012.26.3705","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.715297802.790752808","asserted-by":"object"}]},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}