{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:11:52Z","timestamp":1788448312196,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nasal polyposis (NP) is a chronic inflammatory disease of unknown etiology that impairs quality of life (QoL). The role of atopy in NP is not established. The aim of this study was to describe the clinical characteristics and QoL in a broad sample of patients with NP and to evaluate the influence of allergy on this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A multicenter, observational, cross-sectional study was conducted in 67 allergy units in Spain. NP and nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity were diagnosed following EP\n                      <jats:sup>3<\/jats:sup>\n                      OS guidelines. Rhinitis and asthma were classified following Allergic Rhinitis and Its Impact on Asthma and the Global Initiative for Asthma guidelines, respectively. Skin tests with a battery of aeroallergens were performed on all patients. A visual analog scale (VAS) and Short-Form 12 (SF-12) and 31-item Rhinosinusitis Outcome Measure (RSOM 31) questionnaires were completed by all the patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 671 patients included, 611 were evaluable. Mean age was 46 years and 50% of patients were men. Also, 50% were atopic. Asthma was present in 66% of patients and NSAID hypersensitivity was present in 26%. The most frequent symptoms were nasal congestion and rhinorrhea. Mean value of VAS was 58.6. Global health and bodily pain were the items most frequently identified in the SF-12 questionnaire and nasal and ocular symptoms in the RSOM-31 questionnaire. There was a good correlation between VAS score and QoL (p &lt; 0.0001). Rhinitis was more severe in nonallergic patients. Asthma was more frequent in atopic patients, whereas ASA triad was more frequent in nonatopic patients. Atopic patients showed higher VAS scores and worse QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Atopic NP patients showed worse QoL, higher incidence of asthma and a less severe form of rhinitis than non-atopic patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2012.26.3792","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T11:46:52Z","timestamp":1346845612000},"page":"e126-e131","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Aeroallergen Sensitization Influences Quality of Life and Comorbidities in Patients with Nasal Polyposis"],"prefix":"10.1177","volume":"26","author":[{"given":"Ignacio","family":"D\u00e1vila","sequence":"first","affiliation":[{"name":"Allergy Service, University Hospital of Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Rond\u00f3n","sequence":"additional","affiliation":[{"name":"Allergy Service, Carlos Haya Hospital, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Navarro","sequence":"additional","affiliation":[{"name":"UGC Intercentros Valme-Roc\u00edo de Alergolog\u00eda, Hospital El Tomillar, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Encarnaci\u00f3n","family":"Ant\u00f3n","sequence":"additional","affiliation":[{"name":"Allergy Service, University Hospital Marqu\u00e9s de Valdecilla, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Colas","sequence":"additional","affiliation":[{"name":"Allergy Service, Hospital Cl\u00ednico-Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Dordal","sequence":"additional","affiliation":[{"name":"Allergy Service, Hospital Municipal de Badalona, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Allergy Service, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Fern\u00e1ndez-Parra","sequence":"additional","affiliation":[{"name":"Allergy Service, Hospital El Bierzo, Ponferrada, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Lluch-Bernal","sequence":"additional","affiliation":[{"name":"Allergy Service, Hospital Virgen del Valle, Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Matheu","sequence":"additional","affiliation":[{"name":"Allergy Service, Hospital del T\u00f3rax (Ofra), Complejo Hospitalario Universitario NSC, Unidad de Investigaci\u00f3n, Hospital Universitario NS Candelaria, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Montoro","sequence":"additional","affiliation":[{"name":"Allergy Unit, Hospital Universitario Arnau de Vilanova, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Ces\u00e1rea","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Allergy Unit, CE Virgen de la Cinta, Hospital Juan Ram\u00f3n Jimenez, Huelva, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Valero","sequence":"additional","affiliation":[{"name":"Allergy Unit, Servei de Pneumologia i All\u00e8rgia Respirat\u00f3ria, Hospital Cl\u00ednic, Barcelona, Spain, Institut d'Investigacions Biom\u00e9diques August Pi i Sunyer (IDIBAPS), Centro de Investigaci\u00f3n Biom\u00e9dica en red en Enfermedades Respiratorias 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