{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:16:01Z","timestamp":1777385761103,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study explores effects of budesonide on the proliferation of nasal polyp epithelial cells and expression of the glucocorticoid receptor (GR) alpha in nasal polyp epithelial cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Primary cultured, purified, and identified the epithelial cells collected from nasal polyps. The proliferation of nasal polyp epithelial cells was examined by a cell counting kit, and expression of GR-alpha mRNA in nasal polyp epithelial cells was examined by reverse transcription polymerase chain reaction, after training nasal polyp epithelial cells in budesonide solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The average survival rate of nasal polyp epithelial cells was the lowest in 1 \u00d7 10\n                      <jats:sup>\u22126<\/jats:sup>\n                      M budesonide solution (29.284 \u00b1 0.311%), compared with other concentrations. Budesonide at 1 \u00d7 10\n                      <jats:sup>\u22128<\/jats:sup>\n                      M caused down-regulation of GR-alpha mRNA expression levels at 6 and 12 ours, compared with the 0-hour group (p &lt; 0.001); compared with the 0-hour group, there were significantly lower expression levels of GR-alpha mRNA at both 24 and 48 hours (p &lt; 0.001); Expression of GR-alpha mRNA at either 48 or 12 hours was not significantly different from that at 24 hours.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Budesonide can significantly inhibit the proliferation of nasal polyp epithelial cells, down-regulate the expression of GR-alpha mRNA in nasal polyp epithelial cells with time dependence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2013.27.3862","type":"journal-article","created":{"date-parts":[[2013,3,31]],"date-time":"2013-03-31T01:03:09Z","timestamp":1364691789000},"page":"123-127","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Budesonide on the Expression of the Glucocorticoid Receptor-\n                    <i>\u03b1<\/i>\n                    in Nasal Polyp Epithelial Cells"],"prefix":"10.1177","volume":"27","author":[{"given":"De-Sheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Affiliated Union Hospital of Fujian Medical University, Fujian, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin-Song","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Affiliated Union Hospital of Fujian Medical University, Fujian, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Chun","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Affiliated Union Hospital of Fujian Medical University, Fujian, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"bibr1-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565110-00006"},{"key":"bibr2-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00830.x"},{"key":"bibr3-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3418"},{"key":"bibr4-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3523"},{"key":"bibr5-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00363.2001"},{"key":"bibr6-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310017063"},{"key":"bibr7-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00635.x"},{"key":"bibr8-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.1.4024"},{"key":"bibr9-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70311-1"},{"key":"bibr10-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.3.9116996"},{"key":"bibr11-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.16.5899"},{"key":"bibr12-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)69104-5"},{"key":"bibr13-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)71692-X"},{"key":"bibr14-ajra.2013.27.3862","first-page":"2295s","volume":"49","author":"Vedeckis WV","year":"1989","journal-title":"Cancer Res"},{"key":"bibr15-ajra.2013.27.3862","first-page":"1336","volume":"8","author":"Vig E","year":"1994","journal-title":"Mol Endocrinol"},{"key":"bibr16-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1210\/endo.133.1.8319574"},{"key":"bibr17-ajra.2013.27.3862","first-page":"1764","volume":"8","author":"Burnstein KL","year":"1994","journal-title":"Mol Endocrinol"},{"key":"bibr18-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9084(91)90074-B"},{"key":"bibr19-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1440301"},{"key":"bibr20-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1210\/mend-2-12-1256"},{"key":"bibr21-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.2500\/105065801781329446"},{"key":"bibr22-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01745.x"},{"key":"bibr23-ajra.2013.27.3862","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62222-3"}],"container-title":["American Journal of Rhinology &amp; 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