{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:16:36Z","timestamp":1777385796723,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on the expression and role of matrix metalloproteinases (MMPs) and their tissue inhibitors (tissue inhibitor of metalloproteinases [TIMPs]) in chronic rhinosinusitis with nasal polyps (CRSwNPs) are contradictory, partly because or the use of different techniques of tissue analysis. The aim of this study was to establish a qualitative\/semiquantitative method of analysis on the expression of these remodeling markers in different tissue structures and eosinophils in both NPs and nasal mucosa (NM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>NP tissues were obtained from patients undergoing endoscopic sinus surgery for severe CRSwNPs (n = 33) and NM tissues from patients undergoing nasal corrective surgery (n = 12). MMPs (MMP-1, MMP-2, MMP-7, and MMP-9) and TIMP type 1 (TIMP-1) expression were evaluated by immunohistochemistry in tissue structures (epithelium, glands, vessels, and extracellular matrix [ECM]) and eosinophils. Tissue eosinophilia was also analyzed in NP tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MMPs and TIMP-1 expression were found in the epithelium, glands, vessels, and ECM (in both NM and NP) and in eosinophils (only in NP). Significant (p &lt; 0.01) findings were observed in NP compared with NM: increase in MMP-1 in ECM; decrease in MMP-2 in glands, vessels, and epithelium; decrease in MMP-7 in all tissue structures; increase in MMP-9 in ECM and decrease in epithelium and glands; and no differences in TIMP-1. NP tissues showed a clear eosinophilic inflammation compared with NM (p &lt; 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that (1) metalloproteases (MMP-1, MMP-2, MMP-7, and MMP-9) may play an important role in the remodeling of NPs and\/or in NP formation and (2) a differential analysis of tissue structures and inflammatory cells should be performed when studying remodeling marker expression and regulation in the upper airways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2013.27.3908","type":"journal-article","created":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T05:36:15Z","timestamp":1369719375000},"page":"e69-e74","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Differential Expression of Remodeling Markers by Tissue Structure in Nasal Polyposis"],"prefix":"10.1177","volume":"27","author":[{"given":"Francisco de Borja","family":"Callejas","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednic, Universitat de Barcelona, CIBER de Enfermedades Respiratorias"},{"name":"Immunoall\u00e8rgia Respirat\u00f2ria Cl\u00ednica i Experimental, Institut d'Investigacions Biomediques August Pi i Sunyer"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"Picado","sequence":"additional","affiliation":[{"name":"Immunoall\u00e8rgia Respirat\u00f2ria Cl\u00ednica i Experimental, Institut d'Investigacions Biomediques August Pi i Sunyer"},{"name":"Departments of Pneumology and Allergy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asunci\u00f3n","family":"Mart\u00ednez-Ant\u00f3n","sequence":"additional","affiliation":[{"name":"Immunoall\u00e8rgia Respirat\u00f2ria Cl\u00ednica i Experimental, Institut d'Investigacions Biomediques August Pi i 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