{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:17:35Z","timestamp":1777385855004,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immunization with bacille Calmette-Gu\u00e9rin (BCG) has been shown to augment T helper (Th) 1 biased response and hence gives protection against developing allergies. However, results across the studies have been inconclusive and there is no Indian study verifying this association. We explored the link between BCG vaccination and prevalence of allergic diseases among school children of Chandigarh, North India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a large cross-sectional study, children aged 7\u201314 years, with and without documentation and\/or scar consistent with BCG vaccination, were examined over a period of 2 years and 5 months with the help of a questionnaire-based survey followed by skin-prick test (SPT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 10,028 children were included. The mean age was 11.04 \u00b1 2.8 years and M\/F ratio was 1.1:1. Among them, 77.7% had documentation of BCG vaccination, 17% had a BCG-like scar but no documentation and 5.3% had no scar\/documentation. SPT was performed on 1614 (16%) children. In the BCG group (vaccination and\/or scar) 16.7% were atopic (positive SPT) compared with 21.3% in no BCG (no vaccination\/scar). T prevalence of allergic diseases among BCG\n                      <jats:sup>+<\/jats:sup>\n                      subjects was 10.1%. Among these, asthma was the commonest one (6.1%), followed by rhinitis (3.5%) and eczema (0.5%). There was significant negative correlation between BCG positivity, atopy (p = 0.037), and allergic diseases as a whole (p = 0.028), but on independent analysis the negative correlation was strongest with allergic rhinitis (p = 0.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BCG vaccination is associated with lower prevalence of allergic disorders in Indian children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2013.27.3940","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T12:38:30Z","timestamp":1374669510000},"page":"e107-e112","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Bacille Calmette-Gu\u00e9rin Vaccination is Associated with Lower Prevalence of Allergic Diseases in Indian Children"],"prefix":"10.1177","volume":"27","author":[{"given":"Meenu","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Post-Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi Ranjan","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lata","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Post-Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, School of Public Health, Post-Graduate Institute of Medical Education and Research, Chandigarh, India Funded by ICMR Task Force for Asthma, Indian Council of Medical Research (ICMR), New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,4,27]]},"reference":[{"key":"bibr1-ajra.2013.27.3940","first-page":"13","volume":"48","author":"Aggarwal A.N.","year":"2006","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"bibr2-ajra.2013.27.3940","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0218.58389"},{"key":"bibr3-ajra.2013.27.3940","unstructured":"Alarming rise of Allergy cases in the city. 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