{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:18:20Z","timestamp":1777385900896,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acetylsalicylic acid (ASA; aspirin) is a well-known inducer of pseudoallergic response in patients with chronic rhinosinusitis with polyps (CRSwPs). The mechanism that leads to this response remains unclear. This study was designed to measure and compare the local and systemic inflammatory response to aspirin challenge in patients with CRSwPs who develop either a nasobronchial response (NBR) or a nasal response (NR), and compare it with nonresponders (non-Rs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The three groups underwent nasal wash before ASA challenge, and inflammatory mediators were measured in the nasal wash as well as in serum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 25 CRSwP patients were enrolled. The NBR patients (n = 13) had a significantly longer mean disease duration and a higher mean serum leukotriene E\n                      <jats:sub>4<\/jats:sub>\n                      (LTE\n                      <jats:sub>4<\/jats:sub>\n                      ) level than the NR (n = 6) and non-R (n = 6) patients (39.2 \u00b1 9.7 months, 21 \u00b1 8.8 months, and 22.8 \u00b1 11.2 months, respectively, and 4221 \u00b1 1205 pg\/mL, 1430 \u00b1 605 pg\/mL, and 857 \u00b1 461 pg\/mL, respectively). The NBR and NR patients had a larger mean number of nasal eosinophils than the non-R group (52.8 \u00b1 28.8 cells\/\u03bcL, 47 \u00b1 21.3 cells\/\u03bcL, and 19.3 \u00b1 13.4 cells\/\u03bcL, respectively). The tryptase, albumin, nasal LTE\n                      <jats:sub>4<\/jats:sub>\n                      , and prostaglandin E\n                      <jats:sub>2<\/jats:sub>\n                      levels were not significantly different between the three groups in any examined combination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The nasal eosinophil and serum LTE\n                      <jats:sub>4<\/jats:sub>\n                      levels correlate with aspirin sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2013.27.3961","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T23:54:05Z","timestamp":1385164445000},"page":"e170-e173","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Aspirin Challenge in Patients with Chronic Rhinosinusitis with Polyps Correlates with Local and Systemic Inflammatory Markers"],"prefix":"10.1177","volume":"27","author":[{"given":"Boaz","family":"Forer","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Barzilai Medical Center, Ben Gurion University, Ashkelon, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roee","family":"Landsberg","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Kivity","sequence":"additional","affiliation":[{"name":"Departments of Allergy and Clinical Immunology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"bibr1-ajra.2013.27.3961","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1288\/00005537-199201000-00001","volume":"102","author":"Kennedy DW","year":"1992","journal-title":"Laryngoscope"},{"key":"bibr2-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200405000-00004"},{"key":"bibr3-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2011.25.3660"},{"key":"bibr4-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2012.26.3767"},{"key":"bibr5-ajra.2013.27.3961","first-page":"7","volume":"29","author":"Amar YG","year":"2000","journal-title":"J Otolaryngol"},{"key":"bibr6-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.2500\/105065897781446702"},{"key":"bibr7-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62468-4"},{"key":"bibr8-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199004000-00003"},{"key":"bibr9-ajra.2013.27.3961","first-page":"847","volume":"41","author":"Hoffmann D","year":"1989","journal-title":"Trans Pa Acad Ophthalmol Otolaryngol"},{"key":"bibr10-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.4.367"},{"key":"bibr11-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb01195.x"},{"key":"bibr12-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.03.002"},{"key":"bibr13-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013508"},{"key":"bibr14-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1159\/000053811"},{"key":"bibr15-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70052-8"},{"key":"bibr16-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-6-11"},{"key":"bibr17-ajra.2013.27.3961","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/02770908709070955","volume":"24","author":"Widal F","year":"1987","journal-title":"J Asthma"},{"key":"bibr18-ajra.2013.27.3961","first-page":"1287","volume":"127","author":"Mardiney M","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"bibr19-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.2500\/108854186779047717"},{"key":"bibr20-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90222-P"},{"key":"bibr21-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/140.1.148"},{"key":"bibr22-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:24:2:159"},{"key":"bibr23-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70002-1"},{"key":"bibr24-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.5.7735581"},{"key":"bibr25-ajra.2013.27.3961","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23259"}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2013.27.3961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2500\/ajra.2013.27.3961","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2013.27.3961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:34:26Z","timestamp":1777368866000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2500\/ajra.2013.27.3961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.2500\/ajra.2013.27.3961"],"URL":"https:\/\/doi.org\/10.2500\/ajra.2013.27.3961","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}