{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:19:31Z","timestamp":1777385971637,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>P-glycoprotein (P-gp) is a membrane-bound efflux pump that is up-regulated in eosinophilic chronic rhinosinusitis and participates in epithelial cytokine secretion. Osteitis is associated with eosinophilic inflammation and may represent a method to predict patients with P-gp overexpression. The purpose of this article was to determine whether P-gp overexpression and increased osteitis scores are associated in patients with chronic rhinosinusitis (CRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An Institutional Review Board-approved study was performed using sinus tissue in 38 patients with CRS. P-gp expression was calculated using quantitative fluorescent immunohistochemistry to generate an epithelial-to-background staining ratio. Patients were stratified into low and high P-gp expression groups. Osteitis was scored radiologically using the Kennedy Osteitis Score (KOS) and Global Osteitis Score (GOS). Serum eosinophilia was assessed. KOS and GOS were compared using a Pearson's correlation coefficient. Osteitis scores and serum eosinophil concentrations between P-gp expression groups were compared using a nonparametric Mann-Whitney U test (two tailed).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 38 patients, 7(18.42%) had high P-gp expression (mean \u00b1 SD, 4.86 \u00b1 1.33) whereas 31(81.57%) had low expression ratios (1.93 \u00b1 0.45). No patients in the high P-gp expression group had undergone prior surgery. Median serum eosinophil values were significantly greater in the high versus low P-gp expression group (6.98 \u00b1 2.17 versus 2.36 \u00b1 1.38, p &lt; 0.001). GOS and KOS values were significantly greater in the high versus low P-gp expression group (15.86 \u00b1 4.91 versus 6.29 \u00b1 1.25 and 4.55 \u00b1 4.33 verus 2.23 \u00b1 1.71; p &lt; 0.001). KOS and GOS values were significantly correlated (r = 0.835; p &lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Increased osteitis burden as measured by either the KOS or the GOS is associated with creased P-gp membranous expression in CRS. Radiographic quantification of osteitis may therefore be used to identify patients with P-gp overexpression thereby providing a novel potential therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2014.28.4011","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T19:47:16Z","timestamp":1395172036000},"page":"99-102","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Osteitis is Associated with P-Glycoprotein Overexpression in Patients with Chronic Sinusitis without Nasal Polyps"],"prefix":"10.1177","volume":"28","author":[{"given":"Ceren","family":"G\u00fcnel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Adnan Menderes University Medical School Hospital, Ayd\u0131n, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel E.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Departments of Otology and Laryngology and Ear Infirmary Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin S.","family":"Bleier","sequence":"additional","affiliation":[{"name":"Departments of Otology and Laryngology and Ear Infirmary Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"bibr1-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21176"},{"key":"bibr2-ajra.2014.28.4011","first-page":"299","volume":"50","author":"Snidvongs K.","year":"2012","journal-title":"Rhinology"},{"key":"bibr3-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21113"},{"key":"bibr4-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21166"},{"key":"bibr5-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21004"},{"key":"bibr6-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21135"},{"key":"bibr7-ajra.2014.28.4011","first-page":"1","volume":"23","author":"Fokkens W.J.","year":"2012","journal-title":"Rhinol Suppl"},{"key":"bibr8-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2857"},{"key":"bibr9-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2010.02218.x"},{"key":"bibr10-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000124938.46948.c7"},{"key":"bibr11-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60895-1"},{"key":"bibr12-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3909"},{"key":"bibr13-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510290045035"},{"key":"bibr14-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.1177\/194589240201600606"},{"key":"bibr15-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.1177\/194589240201600301"},{"key":"bibr16-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32835ac656"},{"key":"bibr17-ajra.2014.28.4011","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3222"}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2014.28.4011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2500\/ajra.2014.28.4011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2014.28.4011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:34:37Z","timestamp":1777368877000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2500\/ajra.2014.28.4011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.2500\/ajra.2014.28.4011"],"URL":"https:\/\/doi.org\/10.2500\/ajra.2014.28.4011","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}