{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:28:39Z","timestamp":1780493319194,"version":"3.54.1"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The causal factor for the perpetuation of the inflammatory process in chronic rhinosinusitis with nasal polyps (CRSwNPs) has been extensively studied. However, little is known about the influence of cell death in this disease. Thus, the molecular assessment of mechanisms involved in apoptosis might shed light on the pathogenesis of CRSwNPs. This study was designed to evaluate the gene expression of different apoptotic factors in patients with NPs compared with control patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The mRNA expression of the apoptosis mediators caspase 3, 7, and 9 and of p53 protein was analyzed using quantitative reverse transcription\u2013polymerase chain reaction in 25 NPs and 18 control samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed significantly lower expression of p53 and caspase 3 and 9 in patients with CRSwNPs compared with the controls, whereas caspase 7 expression was not significantly different from the controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The reduced expression of these apoptosis factors in CRSwNPs might be related to higher proliferation and the perpetuation of inflammatory cells hindering the control of the disease. A better understanding of the possible influence of apoptosis factors on CRSwNPs could provide rationale for future therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2014.28.4022","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T18:44:14Z","timestamp":1399574654000},"page":"187-191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Expression of Apoptosis Mediators p53 and Caspase 3, 7, and 9 in Chronic Rhinosinusitis with Nasal Polyposis"],"prefix":"10.1177","volume":"28","author":[{"given":"Daniel Salgado","family":"K\u00fcpper","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana C. P.","family":"Valera","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Malinsky","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Maria","family":"Milanezi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Tamashiro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma T.","family":"Anselmo-Lima","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"bibr1-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199103000-00015"},{"key":"bibr2-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.4.717"},{"key":"bibr3-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00688.x"},{"key":"bibr4-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00109803a"},{"key":"bibr5-ajra.2014.28.4022","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.4049\/jimmunol.158.8.3902","volume":"158","author":"Simon H.U.","year":"1997","journal-title":"J Immunol"},{"key":"bibr6-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2012.26.3802"},{"key":"bibr7-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2003.10.009"},{"key":"bibr8-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1110\/ps.04789804"},{"key":"bibr9-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000207"},{"key":"bibr10-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-009-1905-4"},{"key":"bibr11-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900030071009"},{"key":"bibr12-ajra.2014.28.4022","first-page":"160","volume":"37","author":"Lavezzi A.","year":"1999","journal-title":"Rhinology"},{"key":"bibr13-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1177\/147323000703500208"},{"key":"bibr14-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1179-1"},{"key":"bibr15-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900603"},{"key":"bibr16-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino50E2"},{"key":"bibr17-ajra.2014.28.4022","first-page":"815","volume":"24","author":"Pacova H.","year":"2009","journal-title":"Histol Histopathol"},{"key":"bibr18-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.3.316"},{"key":"bibr19-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.09.013"},{"key":"bibr20-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000361"},{"key":"bibr21-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.30"},{"key":"bibr22-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008363200"},{"key":"bibr23-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707715105"},{"key":"bibr24-ajra.2014.28.4022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07330.x"}],"container-title":["American Journal of Rhinology &amp; 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