{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:14:19Z","timestamp":1779898459823,"version":"3.53.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sensory attributes of intranasal corticosteroids, such as rundown to the back of the throat, may influence patient treatment preferences. This study compares the nasal deposition and nasal retention of a radiolabeled solution of ciclesonide nasal aerosol (CIC-hydrofluoroalkane [HFA]) with a radiolabeled suspension of mometasone furoate monohydrate aqueous nasal spray (MFNS) in subjects with either perennial allergic rhinitis (AR) or seasonal AR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this open-label, single-dose, randomized, crossover scintigraphy study, 14 subjects with symptomatic AR received a single dose of radiolabeled 74-\u03bcg CIC-HFA (37 \u03bcg\/spray, 1 spray\/each nostril) via a nasal metered-dose inhaler or a single dose of radiolabeled 200-\u03bcg MFNS (50 \u03bcg\/spray, 2 sprays\/each nostril), with a minimum 5-day washout period between treatments. Initial deposition (2 minutes postdose) of radiolabeled CIC-HFA and MFNS in the nasal cavity, nasopharynx, and on nasal wipes, and retention of radioactivity in the nasal cavity and nasal run-out on nasal wipes at 2, 4, 6, 8, and 10 minutes postdose were quantified with scintigraphy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 2 and 10 minutes postdose, deposition of radiolabeled CIC-HFA was significantly higher in the nasal cavity versus radiolabeled MFNS (99.42% versus 86.50% at 2 minutes, p = 0.0046; and 81.10% versus 54.31% at 10 minutes, p &lt; 0.0001, respectively; p values unadjusted for multiplicity). Deposition of radioactivity on nasal wipes was significantly higher with MFNS versus CIC-HFA at all five time points, and posterior losses of radiolabeled formulation were significantly higher with MFNS at 6, 8, and 10 minutes postdose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this scintigraphic study, significantly higher nasal deposition and retention of radiolabeled aerosol CIC-HFA were observed versus radiolabeled aqueous MFNS in subjects with AR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2014.28.4026","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T04:10:32Z","timestamp":1392610232000},"page":"117-121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Nasal Deposition of Ciclesonide Nasal Aerosol and Mometasone Aqueous Nasal Spray in Allergic Rhinitis Patients"],"prefix":"10.1177","volume":"28","author":[{"given":"Ivor A.","family":"Emanuel","sequence":"first","affiliation":[{"name":"San Francisco Ear, Nose, Throat, & Allergy, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Blaiss","sequence":"additional","affiliation":[{"name":"Allergy and Asthma Care, Germantown, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli O.","family":"Meltzer","sequence":"additional","affiliation":[{"name":"Allergy & Asthma Medical Group and Research Center, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Evans","sequence":"additional","affiliation":[{"name":"Quotient Clinical, Ltd., Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson","family":"Connor","sequence":"additional","affiliation":[{"name":"Quotient Clinical, Ltd., Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"bibr1-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.013"},{"key":"bibr2-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115569"},{"key":"bibr3-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2007.28.2991"},{"key":"bibr4-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.10.014"},{"key":"bibr5-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118891"},{"key":"bibr6-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.003"},{"key":"bibr7-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2011.32.3438"},{"key":"bibr8-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610328104"},{"key":"bibr9-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S4051"},{"key":"bibr10-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.01.031"},{"key":"bibr11-ajra.2014.28.4026","volume-title":"Omnaris (ciclesonide) nasal spray package insert.","year":"2011"},{"key":"bibr12-ajra.2014.28.4026","volume-title":"Zetonna (ciclesonide) nasal aerosol package insert.","year":"2012"},{"key":"bibr13-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61393-2"},{"key":"bibr14-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200323010-00005"},{"key":"bibr15-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2013.34.3705"},{"key":"bibr16-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2014.35.3725"},{"key":"bibr17-ajra.2014.28.4026","first-page":"S29","volume":"61","author":"The National Allergy Survey Assessing Limitations (NASAL)","year":"2012","journal-title":"J Fam Pract"},{"key":"bibr18-ajra.2014.28.4026","volume-title":"Work with ionising radiation: Ionising Radiation Regulations 1999.","author":"Health and Safety Executive.","year":"2000"},{"key":"bibr19-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.1089\/jam.1997.10.187"},{"key":"bibr20-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(97)00067-7"},{"key":"bibr21-ajra.2014.28.4026","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100101380"},{"key":"bibr22-ajra.2014.28.4026","first-page":"77","volume":"25","author":"Newman S.P.","year":"1987","journal-title":"Rhinology"},{"key":"bibr23-ajra.2014.28.4026","first-page":"111","volume":"26","author":"Newman S.P.","year":"1988","journal-title":"Rhinology"}],"container-title":["American Journal of Rhinology &amp; 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