{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:44:31Z","timestamp":1785901471013,"version":"3.56.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Septic cavernous sinus thrombosis (SCST) is a rare but severe complication of acute bacterial sinusitis. Evaluations of advances in imaging techniques as well as in medical and surgical treatment are hampered by the lack of recent studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aim to report our experience in the management of SCST in patients with acute bacterial sphenoid sinusitis over the past 10 years and to discuss the initial work-up and treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective study of patients admitted for SCST related to acute sinusitis at a tertiary care center between 2003 and 2013. Clinical charts were reviewed for demographics, clinical presentations, imaging and microbiologic findings, medical and surgical treatments, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven patients were treated for SCST. Sphenoid sinus was involved in all cases. The most frequent presenting signs included headache (100%), cranial nerve impairment (86%), fever (71%), and orbital symptoms (71%). Diagnosis was confirmed by a cerebral contrast-enhanced CT scan in all cases. Four patients (57%) had an additional intracranial complication. The average time between clinical onset and diagnosis was 13.7 days. All patients were treated by high-dose i.v. antibiotics, anticoagulation therapy, and surgical endoscopic drainage of the infected sinuses. This treatment strategy resulted in a mortality rate of 0%, but four out of the seven patients developed transient or permanent neurologic deficits, including one with permanent unilateral visual loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of high-dose i.v. antibiotics, anticoagulation therapy, and endoscopic drainage of the infected paranasal sinus is an effective strategy for the treatment of SCST, but long-term sequelae remain frequent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2015.29.4127","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T19:29:30Z","timestamp":1421263770000},"page":"e7-e12","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Septic Cavernous Sinus Thrombosis Secondary to Acute Bacterial Sinusitis: A Retrospective Study of Seven Cases"],"prefix":"10.1177","volume":"29","author":[{"given":"Franklin","family":"Liz\u00e9","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Lariboisi\u00e8re Hospital, Paris VII University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Verillaud","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Lariboisi\u00e8re Hospital, Paris VII University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Vironneau","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Lariboisi\u00e8re Hospital, Paris VII University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Blancal","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Lariboisi\u00e8re Hospital, Paris VII University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Guichard","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Lariboisi\u00e8re Hospital, Paris VII University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Kania","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Lariboisi\u00e8re Hospital, Paris VII University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Herman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Lariboisi\u00e8re Hospital, Paris VII University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"bibr1-ajra.2015.29.4127","first-page":"59","volume":"47","author":"Bayonne E.","year":"2009","journal-title":"Rhinology"},{"key":"bibr2-ajra.2015.29.4127","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199103000-00003"},{"key":"bibr3-ajra.2015.29.4127","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199811000-00009"},{"key":"bibr4-ajra.2015.29.4127","first-page":"265","volume":"55","author":"Albu S.","year":"2001","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"bibr5-ajra.2015.29.4127","doi-asserted-by":"publisher","DOI":"10.1258\/002221502760237920"},{"key":"bibr6-ajra.2015.29.4127","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(09)60306-5"},{"key":"bibr7-ajra.2015.29.4127","doi-asserted-by":"publisher","DOI":"10.1080\/01676830500506077"},{"key":"bibr8-ajra.2015.29.4127","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198603000-00002"},{"key":"bibr9-ajra.2015.29.4127","doi-asserted-by":"publisher","DOI":"10.1177\/014107680609900921"},{"key":"bibr10-ajra.2015.29.4127","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215110000113"},{"key":"bibr11-ajra.2015.29.4127","first-page":"617","volume":"19","author":"Schuknecht B.","year":"1998","journal-title":"Am J Neuroradiol"},{"key":"bibr12-ajra.2015.29.4127","first-page":"152","volume":"43","author":"Deveze A.","year":"2005","journal-title":"Rhinology"},{"key":"bibr13-ajra.2015.29.4127","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880240106014"},{"key":"bibr14-ajra.2015.29.4127","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.4.517"},{"key":"bibr15-ajra.2015.29.4127","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004015908"},{"key":"bibr16-ajra.2015.29.4127","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3943"}],"container-title":["American Journal of Rhinology &amp; 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