{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:45:24Z","timestamp":1781757924438,"version":"3.54.5"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis (CRS) is a common illness, yet little is known about its pathogenesis, including the role played by respiratory viruses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A transversal prospective study was conducted to analyze the seasonality of CRS using real-time polymerase chain reaction to detect respiratory virus genomes in secretions and tissue samples from patients with CRS with and without nasal polyps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The frequency of viral detection was 41% (31\/75). The respiratory virus most frequently detected was human rhinovirus, found in 18 patients (24%), followed by human metapneumovirus, human enterovirus, human respiratory sincicial virus, human adenovirus, human bocavirus, human coronavirus, and human influenza virus, detected in 12 (16%), five (6.6%), four (5.3%), four (5.3%), two (2.6%), two (2.6%), and one (1.3%) patient(s), respectively. Although none of the patients presented symptoms when the samples were collected, there was a peak in detection of the most prevalent virus in the autumn and winter seasons of both years, similar to the pattern that occurs in acute conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The pattern of respiratory virus seasonality found in nasal mucosa, polyps, and paranasal sinus samples in patients with CRS reinforces the possibility of asymptomatic respiratory viral infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2015.29.4129","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T19:29:30Z","timestamp":1421263770000},"page":"19-22","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["The Seasonality of Respiratory Viruses in Patients with Chronic Rhinosinusitis"],"prefix":"10.1177","volume":"29","author":[{"suffix":"Jr","given":"Jesse T.","family":"Lima","sequence":"first","affiliation":[{"name":"Departments of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia E.","family":"Paula","sequence":"additional","affiliation":[{"name":"Cell Biology, University of S\u00e3o Paulo, School of Medicine of Ribeir\u00e3o Preto, Brazil"},{"name":"Virology Research Center, University of S\u00e3o Paulo, School of Medicine of Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Proen\u00e7a-Modena","sequence":"additional","affiliation":[{"name":"Cell Biology, University of S\u00e3o Paulo, School of Medicine of Ribeir\u00e3o Preto, Brazil"},{"name":"Department of Genetics, Evolution, and Bioagents, Institute of Biology, University of Campinas (UNICAMP), Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo C.","family":"Demarco","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme P.","family":"Buzatto","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara H.","family":"Saturno","sequence":"additional","affiliation":[{"name":"Virology Research Center, University of S\u00e3o Paulo, School of Medicine of Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana S.","family":"Delcaro","sequence":"additional","affiliation":[{"name":"Virology Research Center, University of S\u00e3o Paulo, School of Medicine of Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Tamashiro","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana C. 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