{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:18:13Z","timestamp":1789071493206,"version":"build-2803163510"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To further evaluate the efficacy and safety of a pollen blocker cream against dust-mite allergy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter, randomized, double-blind, placebo-controlled, crossover trial was conducted in a Chinese population. Patients diagnosed with perennial allergic rhinitis, sensitive to dust-mite allergy including Dermatophagoides farinae and Dermatophagoides pteronyssinus were randomly allocated to receive a pollen blocker cream or placebo, which was applied and spread evenly to the lower internal nose region three times daily for a total of 30 days. The primary outcome measurements for efficacy were total nasal symptom score (TNSS) and individual nasal symptom score (iNSS). Adverse events were also monitored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After application of a pollen blocker, the mean TNSS decreased from 23.1 to 13.8, the decrease of the pollen blocker group (9.3) was highly significant compared with the placebo group (5.2; p &lt; 0.001). Similarly, the decreases in iNSSs (rhinorrhea, congestion, sneezing, and itching) between the pollen blocker group and the placebo group were also significant (p &lt; 0.05). In addition, in adults, the pollen blocker led to a remarkably significant decrease in TNSS (9.5) compared with placebo (5.4; p &lt; 0.001); in children, the pollen blocker led to a significant decrease in TNSS (8.6) compared with placebo (4.8; p &lt; 0.05). No statistical difference was found in the incidence of adverse events between the two groups (p &gt; 0.05), and no severe systematic reactions were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pollen Blocker is a safe and effective alternative to the drugs for treatment of AR, especially for Chinese people allergic to dust-mite allergy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2015.29.4218","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T10:36:09Z","timestamp":1441881369000},"page":"e129-e133","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy Evaluation of a Pollen Blocker Cream against Dust-Mite Allergy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Crossover Trial"],"prefix":"10.1177","volume":"29","author":[{"given":"Yanqing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, the ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, the Traditional Chinese Medicine Hospital of Jiangsu Province, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, the Second Affiliated Hospital, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, the ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"bibr1-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01549.x"},{"key":"bibr2-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.9001"},{"key":"bibr3-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2009.30.3244"},{"key":"bibr4-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2012.26.3799"},{"key":"bibr5-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3603"},{"key":"bibr6-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2014.6.2.105"},{"key":"bibr7-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2013.867973"},{"key":"bibr8-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01967.x"},{"key":"bibr9-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1603\/ME12036"},{"key":"bibr10-ajra.2015.29.4218","first-page":"683","volume":"22","author":"Chen J.J.","year":"2008","journal-title":"J Clin Otolaryngol Head Neck Surg"},{"key":"bibr11-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1159\/000024301"},{"key":"bibr12-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-32436"},{"key":"bibr13-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.8.979"},{"key":"bibr14-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.06.026"},{"key":"bibr15-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3923"},{"key":"bibr16-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2007.28.2934"},{"key":"bibr17-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.2500\/aap2008.29.3072"},{"key":"bibr18-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1159\/000314884"},{"key":"bibr19-ajra.2015.29.4218","first-page":"264","volume":"22","author":"Xi L.","year":"2012","journal-title":"J Investig Allergol Clin Immunol"},{"key":"bibr20-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2010.31.3329"},{"key":"bibr21-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201190061"},{"key":"bibr22-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60130-X"},{"key":"bibr23-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3531"},{"key":"bibr24-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.6.9704026"},{"key":"bibr25-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1994.tb00246.x"},{"key":"bibr26-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1159\/000234724"},{"issue":"3","key":"bibr27-ajra.2015.29.4218","first-page":"40","volume":"21","author":"del Cuvillo A.","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"key":"bibr28-ajra.2015.29.4218","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.3.968"}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2015.29.4218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2500\/ajra.2015.29.4218","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2500\/ajra.2015.29.4218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:33:35Z","timestamp":1777368815000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2500\/ajra.2015.29.4218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.2500\/ajra.2015.29.4218"],"URL":"https:\/\/doi.org\/10.2500\/ajra.2015.29.4218","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}