{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:16:37Z","timestamp":1777385797025,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Risk factors in adult patients with cystic fibrosis (CF) associated with surgical intervention have not been delineated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify characteristics of adult patients with CF and with chronic rhinosinusitis that predict surgical intervention with endoscopic sinus surgery (ESS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were identified in a tertiary sinus center by the International Classification of Diseases, Ninth Revision codes 277.00-277.03, which represent CF. Charts were reviewed for the CF transmembrane conductance regulator (CFTR) gene mutation, Lund-Mackay score (LMS), the 22-item Sino-Nasal Outcome Test (SNOT-22) score, previous ESS, and occurrence of ESS after presentation. The Fisher exact test was used to test frequency of events between the groups, and the Mann Whitney U test and the t-test were used to compare means among LMS, SNOT-22, and age. The Cox proportional hazard analysis was used to calculate hazard ratios (HR) for the impact of LMS, SNOT-22 score, previous ESS, and CFTR gene mutation status on the occurrence of ESS after presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred and fifteen patients met the inclusion criteria for the study. Patients with a history of surgery more often underwent ESS after presentation (p \u2264 0.01). The LMS and the SNOT-22 score were not significantly different between the groups of previous ESS and no previous ESS (p = 0.23 and p = 0.28, respectively). A severe mutation genotype was predictive of ESS after presentation (p = 0.03). SNOT-22 scores did not differ between the severe and mild groups (36.0 and 32.4, respectively; p = 0.57), but the mean LMS was significantly higher in the severe mutation group (12.5 and 9.7; p \u2264 0.01). Univariate Cox proportional hazard analysis revealed an increased occurrence of ESS for patients with severe mutations (HR, 3.6; p \u2264 0.01) or a history of ESS (HR, 2.3; p \u2264 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The occurrence of ESS in adult patients with CF was predicted by previous ESS intervention as well as the severity of CFTR mutation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2017.31.4385","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T22:03:08Z","timestamp":1486677788000},"page":"44-47","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Factors Influencing the Need for Endoscopic Sinus Surgery in Adult Patients with Cystic Fibrosis"],"prefix":"10.1177","volume":"31","author":[{"given":"Christopher D.","family":"Brook","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Z.","family":"Maxfield","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hena","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad R.","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric H.","family":"Holbrook","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey T.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"bibr1-ajra.2017.31.4385","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3355a"},{"key":"bibr2-ajra.2017.31.4385","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1500ED"},{"key":"bibr3-ajra.2017.31.4385","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"bibr4-ajra.2017.31.4385","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2006.08.015"},{"key":"bibr5-ajra.2017.31.4385","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2013.10.011"},{"key":"bibr6-ajra.2017.31.4385","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2011.01.005"},{"key":"bibr7-ajra.2017.31.4385","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.5.8912731"},{"key":"bibr8-ajra.2017.31.4385","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61162-9"},{"key":"bibr9-ajra.2017.31.4385","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4213"},{"key":"bibr10-ajra.2017.31.4385","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21607"},{"key":"bibr11-ajra.2017.31.4385","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4196"},{"key":"bibr12-ajra.2017.31.4385","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21675"},{"key":"bibr13-ajra.2017.31.4385","first-page":"1985","volume":"18","author":"Savastano 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