{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:16:38Z","timestamp":1777385798363,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between allergic sensitization and radiographic sinus inflammation remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether specific allergen sensitization is correlated with sinonasal radiographic opacification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with chronic sinonasal symptoms were selected and included if they had allergy testing and a computed tomography (CT) of the paranasal sinuses. Data regarding demographic characteristics, in vitro allergy test results, and comorbidities were collected. CTs were reviewed, and an overall Lund-Mackay score (LMS) was calculated for each patient. A two-sample t-test was used to compare mean LMS between patients who were sensitized and patients who were not sensitized. A multiple linear regression model was used to determine whether a relationship existed among LMS and allergy results, asthma, nasal polyps, immunoglobulin E (IgE) level, medication usage, in-season versus out-of-season CTs, age, and sex. Significance was determined at an alpha level of 0.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 437 patients included, of whom, 251 had positive specific allergen test results and 186 had negative test results. A total of 282 patients had allergic rhinitis symptoms without a documented diagnosis of sinusitis, and 155 carried a diagnosis of chronic rhinosinusitis. The mean LMS did not differ between patients who were sensitized and patients who were not sensitized (5.56 versus 5.28; p = 0.61). Linear regression demonstrated an increase in LMS in patients with asthma (p = 0.02), male sex (p &lt; 0.01), elevated IgE (p &lt; 0.01), a history of anaphylaxis (p = 0.03), and nasal polyps (p &lt; 0.01). There was a statistically significant decrease in LMS in patients with an in-season CT (p = 0.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with a positive specific in vitro allergen test result did not have higher overall rates of radiographic sinus inflammation. Asthma, male sex, polyps, elevated IgE, and a history of anaphylaxis were associated with higher LMS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2017.31.4394","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T22:03:08Z","timestamp":1486677788000},"page":"12-15","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["The Association of Allergic Sensitization with Radiographic Sinus Opacification"],"prefix":"10.1177","volume":"31","author":[{"given":"Christopher D.","family":"Brook","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Boston University School of Medicine, Boston, Massachusetts"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob E.","family":"Kuperstock","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Boston University School of Medicine, Boston, Massachusetts"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel J.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew W.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Platt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Boston University School of Medicine, Boston, Massachusetts"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"bibr1-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0242-y"},{"key":"bibr2-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.10.032"},{"key":"bibr3-ajra.2017.31.4394","volume-title":"Current estimates from the National Health Interview Survey, 1995.","author":"Benson V.","year":"1998"},{"key":"bibr4-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.109476"},{"key":"bibr5-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.110961"},{"key":"bibr6-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21258"},{"key":"bibr7-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00813.x"},{"key":"bibr8-ajra.2017.31.4394","first-page":"204","volume":"46","author":"Kirtsreesakul V.","year":"2008","journal-title":"Rhinology"},{"key":"bibr9-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.010"},{"key":"bibr10-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02530.x"},{"key":"bibr11-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20025"},{"key":"bibr12-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31817d01b8"},{"key":"bibr13-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63299-1"},{"key":"bibr14-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4252"},{"key":"bibr15-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.2500\/ar.2014.5.0102"},{"key":"bibr16-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2014.35.3774"},{"key":"bibr17-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2907"},{"key":"bibr18-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60829-0"},{"key":"bibr19-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3062"},{"key":"bibr20-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212100909"},{"issue":"23","key":"bibr21-ajra.2017.31.4394","first-page":"1","author":"Fokkens W.J.","year":"2012","journal-title":"Rhinol Suppl"},{"key":"bibr22-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.004"},{"key":"bibr23-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21394"},{"key":"bibr24-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900116"},{"key":"bibr25-ajra.2017.31.4394","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.119324"}],"container-title":["American Journal of Rhinology &amp; 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