{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:29:16Z","timestamp":1792643356953,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a highly prevalent disease of the nasal cavity and paranasal sinus, but its exact etiology is still unclear and remains a difficult-to-treat condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Endoscopic sinus surgery (ESS) is an effective treatment for medically recalcitrant CRSwNP. There are independent variables that can predict surgical outcomes in patients with CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate ESS efficacy in CRSwNP treatment and to establish prognostic factors for disease recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-five patients with CRSwNP submitted to ESS, and a minimum follow-up of 9 months was selected. Patient demographics, occupational organic exposure (e.g., cotton, fuel gas, wood dust) and inorganic dust exposure (e.g., bleach, metals, cement), comorbidities, previous nasal surgeries, pre- and postoperative symptoms, ear, nose and throat examination findings, computed tomography results, and medical and surgical treatment information were collected from medical records. Statistical analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All rhinologic symptoms improved after surgery, in a statistically significant way, with the best recovery rate for nasal obstruction and the worst for hyposmia. The major and minor complications rates were 1.2 and 15.3%, respectively. Disease recurrence occurred in 31% of the patient, but only 7% required surgical reintervention. Multivariate logistic regression analysis identified occupational dust exposure (p = 0.001) and non-immunoglobulin E (IgE) mediated asthma (p = 0.012) as independent predictive variables in CRSwNP recurrence, unlike the other tested variables: age, sex, IgE-mediated asthma, allergic rhinitis, smoking habits, nasal polyps endoscopic grade, Lund-Mackay score, and postoperative topical corticoid use. The adjusted logistic model presented a good discriminatory capacity with a receiver operating characteristic area under the curve of 0.82 (95% confidence interval, 0.73-0.91; p &lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ESS proved to be an effective treatment in CRSwNP but with a considerable rate of recurrence. These results indicated an important correlation of occupational dust exposure and non-IgE-mediated asthma with disease recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2017.31.4402","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T22:03:08Z","timestamp":1486677788000},"page":"56-62","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":88,"title":["Endoscopic Sinus Surgery for Chronic Rhinosinusitis with Nasal Polyps: Clinical Outcome and Predictive Factors of Recurrence"],"prefix":"10.1177","volume":"31","author":[{"given":"Rafaela","family":"Veloso-Teles","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Cova da Beira Hospital Center, Covilh\u00e3, Portugal"},{"name":"Otorhinolaringology Division, Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Cerejeira","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Cova da Beira Hospital Center, Covilh\u00e3, Portugal"},{"name":"Otorhinolaringology Division, Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"issue":"23","key":"bibr1-ajra.2017.31.4402","first-page":"1","author":"Fokkens W.J.","year":"2012","journal-title":"Rhinol Suppl"},{"key":"bibr2-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200709"},{"key":"bibr3-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino14.016"},{"key":"bibr4-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215112001193"},{"key":"bibr5-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7017.1411"},{"key":"bibr6-ajra.2017.31.4402","first-page":"183","volume":"31","author":"Lund V.J.","year":"1993","journal-title":"Rhinology"},{"key":"bibr7-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01801.x"},{"key":"bibr8-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.005"},{"key":"bibr9-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00688.x"},{"key":"bibr10-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4076"},{"key":"bibr11-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.12.048"},{"key":"bibr12-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000147933.14014.12"},{"key":"bibr13-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4120"},{"key":"bibr14-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1469-7"},{"key":"bibr15-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino15.204"},{"key":"bibr16-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2923"},{"key":"bibr17-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1111\/all.12644"},{"key":"bibr18-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4103"},{"key":"bibr19-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.2500\/105065897780914992"},{"key":"bibr20-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1159\/000088430"},{"key":"bibr21-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2002.00610.x"},{"key":"bibr22-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1177\/194589240301700407"},{"key":"bibr23-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.591"},{"key":"bibr24-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4178"},{"key":"bibr25-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02779.x"},{"key":"bibr26-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1111\/all.12347"},{"key":"bibr27-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156141"},{"key":"bibr28-ajra.2017.31.4402","volume-title":"White Book on Allergy.","author":"Pawankar R.","year":"2011"},{"key":"bibr29-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2016.00220"},{"key":"bibr30-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2015.03.014"},{"key":"bibr31-ajra.2017.31.4402","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.2_Supplement.11S"}],"container-title":["American Journal of Rhinology &amp; 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