{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:18:02Z","timestamp":1777385882493,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare changes in quality of life (QOL) that resulted from sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT) in a real-world clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>SLIT is established as a viable alternative to SCIT for the treatment of allergic rhinitis. Although comparative trials are increasingly available, few studies have examined QOL outcomes between these two treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and five participants who underwent immunotherapy for airborne allergies were enrolled in this prospective, single-center study. Forty participants completed the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) at initiation of therapy, after 6 months, and after 1 year of therapy. Only patients with complete time points were included in the ultimate analysis. Twenty-nine of these participants underwent SCIT and 11 underwent SLIT. The effects of age, sex, and asthma history were also examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The participants in both groups demonstrated improvements in QOL regarding allergic rhinoconjunctivitis over the study period. However, the change in the RQLQ score from both baseline to 6 months and baseline to 1 year was only statistically significant in the SCIT group (p = 0.002, 6 months and 1 year). The participants in the SCIT group also demonstrated statistically significant improvement from baseline to 1 year in the specific domains of practical and emotional functioning, nasal symptoms, non-nasal\/eye symptoms, and sleep. After 1 year, both SCIT and SLIT demonstrated a minimally important difference from baseline in the overall RQLQ score. Age &lt;35 years in the SCIT group had a significant positive impact on QOL improvement (p = 0.038).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although improvements in QOL were noted in both groups, changes in overall scores and the majority of domains only achieved statistical significance in the SCIT group. A small study population and difficulties adhering to immunotherapy dosing schedules in the SLIT group may be contributing factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ajra.2017.31.4465","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T23:51:28Z","timestamp":1504223488000},"page":"310-316","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Quality-of-Life Outcomes in Patients who Underwent Subcutaneous Immunotherapy and Sublingual Immunotherapy in a Real-World Clinical Setting"],"prefix":"10.1177","volume":"31","author":[{"given":"Theresa","family":"Schwanke","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Weill Cornell Medical College, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Carragee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Weill Cornell Medical College, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Bremberg","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Weill Cornell Medical College, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Reisacher","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Weill Cornell Medical College, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,9,1]]},"reference":[{"key":"bibr1-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.1106"},{"key":"bibr2-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1053\/ai.1994.v94.a54939"},{"key":"bibr3-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.589"},{"key":"bibr4-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410702"},{"key":"bibr5-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb01251.x"},{"key":"bibr6-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6552.948"},{"key":"bibr7-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00699.x"},{"key":"bibr8-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60259-1"},{"key":"bibr9-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.02.040"},{"key":"bibr10-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2015.36.3830"},{"key":"bibr11-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32835fcb22"},{"key":"bibr12-ajra.2017.31.4465","first-page":"55","volume":"6","author":"Bernardis P.","year":"1996","journal-title":"J Investig Allergol Clin Immunol"},{"key":"bibr13-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00387.x"},{"key":"bibr14-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62726-3"},{"key":"bibr15-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1996.tb00522.x"},{"key":"bibr16-ajra.2017.31.4465","first-page":"319325","volume":"117","author":"Frew A.J.","year":"2006","journal-title":"J Allergy Clin Iummunol"},{"key":"bibr17-ajra.2017.31.4465","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21561"},{"key":"bibr18-ajra.2017.31.4465","unstructured":"VassarStats: Website for Satistical Computation. 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