{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:13:51Z","timestamp":1777374831261,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Allergy\ufffdRhinol (Providence)"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Macrolides exert anti-inflammatory and immunomodulatory effects beyond their purely antibacterial action, as demonstrated by several bronchial inflammatory disorders, including asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-eight children with newly diagnosed mild persistent asthma were selected by using the Global Initiative for Asthma guidelines and were randomly divided into the study (group I) (n = 36) and control (group II) (n = 22) groups. Mycoplasma pneumonia-specific immunoglobulin G and -specific immunoglobulin M antibody levels of each participant were measured by enzyme-linked immunosorbent assay. Clarithromycin 5 mg\/kg daily and placebo were given to groups I and II, respectively, for 4 weeks. All of the children had maintenance inhaled corticosteroid (fluticasone propionate, one puff twice [50 fig\/puff] daily). Forced expiratory volume in 1 second, forced expiratory flow at 25\u201375% of the pulmonary volume, exhaled nitric oxide value, total IgE level, absolute eosinophil count, and eosinophilic cation protein value were measured at baseline and at the end of the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There are significantly increased forced expiratory volume in 1 second and forced expiratory flow at 25\u201375% of the pulmonary volume levels and decreased exhaled nitric oxide values after the 4-week clarithromycin treatment. The study group also had a decreased peripheral blood absolute eosinophil count and eosinophilic cation protein level, but not for the total IgE level, after the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Four weeks of sub-antimicrobial doses of clarithromycin may improve pulmonary function and decrease eosinophilic inflammation in children with asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2500\/ar.2016.7.0168","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T13:35:40Z","timestamp":1484919340000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of Low-dose Clarithromycin Added to Fluticasone on Inflammatory Markers and Pulmonary Function among Children with Asthma: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"7","author":[{"given":"Kong-Sang","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Taipei City Hospital-Renai Branch, Taipei City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Taipei City Hospital-Renai Branch, Taipei City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che-Sheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Taipei City Hospital-Renai Branch, Taipei City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Mao","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Taipei City Hospital-Renai Branch, Taipei City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"bibr1-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2415"},{"key":"bibr2-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1161-x"},{"key":"bibr3-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-004-0058-5"},{"key":"bibr4-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1159\/000320320"},{"key":"bibr5-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2010.08.003"},{"key":"bibr6-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-009-0086-2"},{"key":"bibr7-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmr.2010.04.002"},{"key":"bibr8-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.11.001"},{"issue":"9","key":"bibr9-ar.2016.7.0168","first-page":"CD004875","volume":"12","author":"Mulholland S.","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr10-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62264-8"},{"key":"bibr11-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1159\/000320319"},{"key":"bibr12-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1159\/000320320"},{"key":"bibr13-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0196"},{"key":"bibr14-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00136712"},{"key":"bibr15-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.02.009"},{"key":"bibr16-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200008000-00007"},{"key":"bibr17-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.01.006"},{"key":"bibr18-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00078-09"},{"key":"bibr19-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.03979.x"},{"key":"bibr20-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2009.12.002"},{"key":"bibr21-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1177\/2049936113497203"},{"key":"bibr22-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2014.09.005"},{"key":"bibr23-ar.2016.7.0168","first-page":"613","volume":"5","author":"Hui D.","year":"2013","journal-title":"J Thorac Dis"},{"key":"bibr24-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1111\/all.12199"},{"key":"bibr25-ar.2016.7.0168","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.4049\/jimmunol.163.5.2909","volume":"163","author":"Tamaoki J.","year":"1999","journal-title":"J Immunol"},{"key":"bibr26-ar.2016.7.0168","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201503-0426OC"}],"container-title":["Allergy &amp; 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