{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:07:48Z","timestamp":1769602068220,"version":"3.49.0"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Procalcitonin has proven to be a sensitive inflammatory marker in non-neutropenic patients. The aim of this study was to determine and compare Procalcitonin with other inflammatory markers in the serum of immunosuppressed children with haematological malignancies; and to assess the predictive value of these mediators in distinguishing between bacterial and non-bacterial infection. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods &amp; Results<\/jats:title><jats:p> The study included 37 children with acute lymphoblastic leukaemia undergoing intensive chemotherapy. They were divided into 3 groups, A, B and C. Group A consisted of 29 neutropenic children with 94 febrile episodes, group B of 20 neutropenic children with 56 afebrile episodes and group C of 13 non-neutropenic children with 58 afebrile episodes. Serial serum levels of PCT, C-Reactive Protein, Neopterin, Interleukin-6 and NO2\/NO3 were all determined on a day-to-day basis for 7 consecutive days. In serum the concentrations of CRP was determined by nephelometry, of PCT by immunoluminescence and of Neopterin, IL-6 and NO2\/NO3 by ELISA method. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> According to our results the Procalcitonin concentration increased rapidly in patients with microbial infection; the response was detectable within 24 hs of the onset of fever due to microbial infections. Procalcitonin is a spesific and sensitive marker of microbial infection in patients with neutropenic fever. The markers, C-Reactive Protein, Interleukin-6 and NO2\/NO3 may not help to identify infections and distinguishe the etiology of infection in neutropenic febrile children with acute lymphoblastic leukaemia. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v30i2.983","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:30:43Z","timestamp":1493767843000},"page":"E75-E85","source":"Crossref","is-referenced-by-count":15,"title":["Serial procalcitonin responses in infection of children with secondary immunodeficiency"],"prefix":"10.3138","volume":"30","author":[{"given":"M.A.","family":"DeLutiis","sequence":"first","affiliation":[{"name":"2nd Department of Paediatrics, Aristotle University of Thessaloniki, University of Chieti School of Medicine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hatzistilianou","sequence":"additional","affiliation":[{"name":"2nd Department of Paediatrics, Aristotle University of Thessaloniki, University of Chieti School of Medicine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rekleity","sequence":"additional","affiliation":[{"name":"2nd Department of Paediatrics, Aristotle University of Thessaloniki, University of Chieti School of Medicine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Athanassiadou","sequence":"additional","affiliation":[{"name":"2nd Department of Paediatrics, Aristotle University of Thessaloniki, University of Chieti School of Medicine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"DeLutiis","sequence":"additional","affiliation":[{"name":"Biology, University of Chieti School of Medicine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Conti","sequence":"additional","affiliation":[{"name":"Immunology Division, University of Chieti School of Medicine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Catriu","sequence":"additional","affiliation":[{"name":"2nd Department of Paediatrics, Aristotle University of Thessaloniki, University of Chieti School of Medicine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/983\/896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v30i2.983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:35:57Z","timestamp":1741890957000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v30i2.983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.25011\/cim.v30i2.983"],"URL":"https:\/\/doi.org\/10.25011\/cim.v30i2.983","relation":{},"ISSN":["1488-2353"],"issn-type":[{"value":"1488-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}