{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T04:27:15Z","timestamp":1741926435423,"version":"3.38.0"},"reference-count":0,"publisher":"University of Toronto Press Inc. (UTPress)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Investigative Medicine"],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p> To show the effect of hypokinesia (HK; diminished movement) on magnesium (Mg2+) loss in Mg2+ deficient subjects and the effect of physical exercise and on Mg2+ deficiency with and without physical exercise: Mg2+ balance, serum Mg2+ concentration and Mg2+ loss were measured. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Studies were conducted on 30 healthy male volunteers during a pre-experimental period of 30 days and an experimental period of 364 days. They were divided equally into three-groups:unrestricted active control subjects (UACS), continuous hypokinetic subjects (CHKS) and periodic hypokinetic subjects (PHKS). The UACS group ran average distances of 9.3 \u00b1 1.2 km.day-l; the CHKS group walked average distances of 0.9 \u00b1 0.2 km.day-l; and the PHKS group walked and ran average distances of 0.9 \u00b1 0.2 km and 9.3 \u00b1 1.2 km.day-l for 5-and 2-days per week, respectively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Mg2+ deficiency, serum Mg2+ level, fecal and urine Mg2+ loss increased (P &lt; 0.05), in the PHKS and CHKS groups compared with their pre-experimental values and the values in the UACS group. However, serum Mg2+ concentration, urine and fecal Mg2+ loss and Mg2+ deficiency increased more (P &lt; 0.05) in the PHKS group than in the CHKS group. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Mg2+ deficiency is more evident with than without physical exercise and Mg2+ loss is exacerbated more with higher than lower Mg2+ deficiency. This indicates that Mg2+ deficiency with and without physical exercise and Mg2+ loss with higher and lower Mg2+ deficiency is due to inability of the body to use Mg2+ and more so when physically healthy subjects are submitted to prolonged periodic than continuous hypokinesia. <\/jats:p><\/jats:sec>","DOI":"10.25011\/cim.v31i1.3137","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T23:26:13Z","timestamp":1493767573000},"page":"E16-E23","source":"Crossref","is-referenced-by-count":3,"title":["Magnesium loss in magnesium deficient subjects with and without physical exercise during prolonged hypokinesia"],"prefix":"10.3138","volume":"31","author":[{"given":"Costas B.","family":"Tsiamis","sequence":"first","affiliation":[{"name":"Medicine Department, School of Medicine, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kostas K.","family":"Kakuris","sequence":"additional","affiliation":[{"name":"European Foundation of Environmental Sciences, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor A.","family":"Deogenov","sequence":"additional","affiliation":[{"name":"European Foundation of Environmental Sciences, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosmas B.","family":"Yerullis","sequence":"additional","affiliation":[{"name":"European Foundation of Environmental Sciences, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1696","container-title":["Clinical and Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/cimonline.ca\/index.php\/cim\/article\/viewFile\/3137\/1266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/utppublishing.com\/doi\/pdf\/10.25011\/cim.v31i1.3137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:15:41Z","timestamp":1741889741000},"score":1,"resource":{"primary":{"URL":"https:\/\/utppublishing.com\/doi\/10.25011\/cim.v31i1.3137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,2,1]]}},"alternative-id":["10.25011\/cim.v31i1.3137"],"URL":"https:\/\/doi.org\/10.25011\/cim.v31i1.3137","relation":{},"ISSN":["1488-2353"],"issn-type":[{"type":"electronic","value":"1488-2353"}],"subject":[],"published":{"date-parts":[[2008,2,1]]}}}